The receptor deleted in colorectal cancer (DCC) mediates the attraction of growing axons to
netrin-1 during brain development. In response to netrin-1 stimulation, DCC becomes a …

SPT6 is a histone chaperone that tightly binds RNA polymerase II (RNAPII) during
transcription elongation. However, its primary role in transcription is uncertain. We used …

Messenger ribonucleoprotein particles (mRNPs) are used to transport mRNAs along
neuronal dendrites to their site of translation. Numerous mRNA-binding and regulatory …

Mutations or dysregulation of nucleoporins (Nups) are strongly associated with neural
developmental diseases, yet the underlying mechanisms remain poorly understood. Here …

Neuronal migration during brain development sets the position of neurons for the
subsequent wiring of neural circuits. To understand the molecular mechanism regulating the …

The Rb/E2F pathway has long been appreciated for its role in regulating cell cycle
progression. Emerging evidence indicates that it also influences physiological events …

Precise control of neuronal migration is essential for the development of the neocortex.
However, the molecular mechanisms underlying neuronal migration remain largely …

Mammalian APeg3 is an antisense gene that is localized within the 3′-untranslated region
of the imprinted gene, Peg3. APeg3 is expressed only in the vasopressinergic neurons of …

Little is known of the intracellular machinery that controls the motility of newborn neurons.
We have previously shown that the proneural protein Neurog2 promotes the migration of …

Mutations of the immunoglobulin superfamily proteins nephrin and Neph1 lead to congenital
nephrotic syndrome in humans or mice. Neph proteins are three closely related molecules …