It is believed that neuropathic pain results from aberrant neuronal discharges although some
evidence suggests that the activation of glia cells contributes to pain after an injury to the …

Peripheral nerve injuries that provoke neuropathic pain are associated with microglial
activation in the spinal cord. We have investigated the characteristics of spinal microglial …

Spinal cord injury (SCI) results in the development of chronic pain syndromes that can
persist indefinitely and cause reductions in quality of life. Treatment of chronic pain after SCI …

Stroke is a group of diseases resulting from cerebral vascular rupture or obstruction and
subsequent brain blood circulation disorder, leading to rapid neurological deficits. Ischemic …

Microglia play a crucial role in the maintenance of neuronal homeostasis in the central
nervous system, and microglia production of immune factors is believed to play an important …

The analgesic properties of antidepressants are often used in the treatment of neuropathy;
however their influence on glial cells in maintaining neuropathic pain is unknown. Our …

The antitumor drug, oxaliplatin, induces neuropathic pain, which is resistant to available
analgesics, and novel mechanism-based therapies are being evaluated for this debilitating …

We examined the effects of minocycline, an anti-inflammatory drug, on functional recovery
following spinal cord injury (SCI). Rats received a mild, weight-drop contusion injury to the …

Minocycline is a semi-synthetic, second-generation tetracycline analog which is effectively
crossing the blood–brain barrier, effective against gram-positive and-negative infections. In …

Minocycline, a semisynthetic tetracycline-derived antibiotic, has been shown to exert anti-
apoptotic, anti-inflammatory, and antioxidant effects. Furthermore, there is rapidly growing …