Previous studies have demonstrated that cocaine use alters availability of brain dopamine
D2 receptors (D2R) and transporters (DAT). The present study examined the effects of low …

Brain imaging studies using positron emission tomography (PET) have shown that long-term
cocaine use is associated with lower levels of dopamine (DA) D2/D3 receptors (D2/D3R); …

Most individuals with cocaine use disorder also use alcohol; however, little is known about
the behavioural and pharmacological mechanisms that promote co‐abuse. For example …

Dopamine neurotransmission is associated with high susceptibility to cocaine abuse.
Positron emission tomography was used in 12 rhesus macaques to determine if dopamine …

OBJECTIVE: Animals self-administer many of the drugs that humans abuse, including
cocaine. This article describes studies using preclinical animal models to differentiate the …

Binding of [11C] cocaine in brain was measured with positron emission tomography in 12
detoxified cocaine abusers and in 20 controls to evaluate if there were changes in cocaine …

Objective: Previous positron emission tomography (PET) imaging studies have
demonstrated that cocaine dependence is associated with a decrease in dopamine type 2 …

The goal of this study was to determine D 1 receptor availability in human cocaine-
dependent (CD) subjects and matched healthy controls (HCs). In addition, the CD subjects …

The dopamine transporter (DAT) is a critical recognition site for cocaine and contributes to its
significant abuse liability. Accordingly, the development of compounds that target the DAT …

We summarize our studies with positron emission tomography investigating the role of
dopamine (DA) in the reinforcing effects of cocaine and methylphenidate in humans and its …