The oocyte is the largest cell found in multicellular organisms. Mitochondria, as the energy
factories for cells, are found in high numbers in oocytes, as they provide the energy for …

Mitochondria are dynamic organelles that change their morphology by active fusion and
fission in response to cellular signaling and differentiation [1, 2]. The in vivo role of …

Mitochondria affect numerous aspects of mammalian reproduction. We investigated whether
the decrease in oocyte quality associated with aging is related to altered mitochondria …

Although the role of oxidative stress in maternal aging and infertility has been suggested, the
underlying mechanisms are not fully understood. The present study is designed to …

Postovulatory aging is known to compromise the oocyte quality as well as subsequent
embryo development in many different animal models, and becomes one of the most …

Mammalian oocytes are long-lived cells in the human body. They initiate meiosis already in
the embryonic ovary, arrest meiotically for long periods in dictyate stage, and resume …

Germinal vesicle transplantation (GVT) has been proposed as a possible treatment to
correct age-related oocyte aneuploidy caused by dysfunctional ooplasm. How healthy …

Optimal maturation of the oocyte depends on its environment and determines embryo
competence, because the embryonic genome is not active until the cleavage stage and new …

Purpose The number of women attempting to conceive between the ages of 36 and 44 has
increased significantly in the last decade. While it is well established that women's …

The development of oocytes and early embryos is dependent on mitochondrial ATP
production. This reliance on mitochondrial activity, together with the exclusively maternal …