Mitochondrial dysfunction is implicated in disease and age-related infertility. Mitochondrial
replacement therapies (MRT) in oocytes or zygotes, such as pronuclear (PNT), spindle (ST) …

Background In human oocytes, as in other mammalian ova, there is a significant variation in
the pregnancy potential, with approximately 20% of oocyte-sperm meetings resulting in …

In recent years, social and cultural trends have resulted in women delaying childbirth,
thereby leading to reproductive senescence as a growing public health problem. We discuss …

With the nucleus as an exception, mitochondria are the only animal cell organelles
containing their own genetic information, called mitochondrial DNA (mtDNA). During oocyte …

Elder women suffer from low or loss of fertility because of decreasing oocyte quality as
maternal aging. As energy resource, mitochondria play pivotal roles in oocyte development …

Currently, maternal aging in women, based on mouse models, is thought to raise oocyte
aneuploidy rates, because chromosome cohesion deteriorates during prophase arrest, and …

Objectives: Correlations between parental age, aneuploidy in germ cells and recent findings
on aetiological factors in mammalian trisomy formation are reviewed. Methods: Data from …

BACKGROUND Highly reactive carbonyl compounds formed during glycolysis, such as
methylglyoxal (MG), can lead to the formation of 'advanced glycation end products'(AGE) …

Objective To reveal the relationship between mitochondrial function in cumulus cells (CCs)
and the aging-related decline in ovarian function and reproductive capacity. Design …

Oocyte quality has long been considered as a main limiting factor for in vitro fertilization
(IVF). In the past decade, extensive observations demonstrated that the mitochondrion plays …