BACKGROUND Highly reactive carbonyl compounds formed during glycolysis, such as
methylglyoxal (MG), can lead to the formation of 'advanced glycation end products'(AGE) …

Oocyte quality has long been considered as a main limiting factor for in vitro fertilization
(IVF). In the past decade, extensive observations demonstrated that the mitochondrion plays …

Objective To reveal the relationship between mitochondrial function in cumulus cells (CCs)
and the aging-related decline in ovarian function and reproductive capacity. Design …

Optimal energy production is required for oocyte and embryo development, and
mitochondrial abnormalities have devastating reproductive consequences. Improvement of …

Mitochondria play vital roles in oocyte functions and they are critical indicators of oocyte
quality which is important for fertilization and development into viable offspring. Quality …

Superovulation by injection of exogenous gonadotropin is the elementary method to
produce in vivo‐derived embryos for embryo transfer in women. Increased oocyte …

The mitochondria, present in almost all eukaryotic cells, produce energy but also contribute
to many other essential cellular functions. One of the unique characteristics of the …

Ovarian aging is characterized by a decline in both the total number and overall quality of
oocytes, the latter of which has been experimentally tied to mitochondrial dysfunction …

Oocyte mitochondrial dysfunction has been proposed as a cause of high levels of
developmental retardation and arrest that occur in human preimplantation embryos …

BACKGROUND Insulin resistance (IR) and hyperinsulinemia compromise fertility in females
and are well-recognized characteristics of anovulatory women with polycystic ovary …