Accumulation of reactive oxygen species during aging leads to programmed cell death
(PCD) in many cell types but has not been explored in mammalian fertilized eggs, in which …

Mitochondria are at the intersection of aging and fertility, with research efforts centered
largely on the role that these specialized organelles play in the relatively rapid decline in …

Female aging is one of the most important factors that impacts human reproduction. With
aging, there is a natural decline in female fertility. The decrease in fertility is slow and steady …

OBJECTIVE (S): To examine the effect of exogenous exposure to hydrogen peroxide (H2O2)
and tumor necrosis factor (TNF)-α on mouse metaphase II (MII) oocyte spindle structure and …

In mammalian ovaries, oocytes are physically coupled to somatic granulosa cells, and this
coupling is crucial for the growth and development of competent oocytes as it mediates the …

Mitochondria is a powerhouse organelle involved in ATP synthesis, calcium signaling,
reactive oxygen species (ROS) by oxidative stress production, cell cycle arrest via apoptosis …

One of the main causes of pregnancy failure and fetus abortion is oocyte aneuploidy, which
is increased with maternal aging. Numerous possible causes of oocyte aneuploidy in aged …

Environmental stress-induced alterations in oocyte mitochondria are suggested to
deleteriously affect developmental competence of the ovarian pool of oocytes. We examined …

Over the past four decades, due to cultural and social changes, women in the developed
world have significantly delayed childbirth. This trend is even worse for patients who attend …

The exchange of nuclear genetic material between oocytes and embryos offers a novel
reproductive option for the prevention of inherited mitochondrial diseases. Mitochondrial …