Human MTHFR-G1793A transition may be a protective mutation against male infertility: a genetic association study and in silico analysis

M Karimian, A Hosseinzadeh Colagar - Human Fertility, 2018 - Taylor & Francis
In this paper, we evaluate the association of the human methylenetetrahydrofolate reductase
(MTHFR)-G1793A transition with male infertility using a case-control study, a meta-analysis …

MTHFR-Ala222Val and male infertility: a study in Iranian men, an updated meta-analysis and an in silico-analysis

H Nikzad, M Karimian, K Sareban… - Reproductive …, 2015 - Elsevier
Methylenetetrahydrofolate reductase (MTHFR) functions as a main regulatory enzyme in
folate metabolism. The association of MTHFR gene Ala222Val polymorphism with male …

Associations of C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) gene with male infertility risk: A meta-analysis

H Hong, Y Hu, X Yu, L Zhou, M Lv, Y Sun… - European Journal of …, 2017 - Elsevier
Purpose Methylenetetrahydrofolate reductase is one of the key enzymes in folate
metabolism. But the association between polymorphism and the risk of male infertility is still …

MTHFR 677C>T Polymorphism Increases the Male Infertility Risk: A Meta-Analysis Involving 26 Studies

M Gong, W Dong, T He, Z Shi, G Huang, R Ren… - PloS one, 2015 - journals.plos.org
Background and Objectives Methylenetetrahydrofolate reductase (MTHFR) polymorphism
may be a risk factor for male infertility. However, the epidemiologic studies showed …

Association of the MTHFR A1298C Variant with Unexplained Severe Male Infertility

A Eloualid, O Abidi, M Charif, B El Houate… - PloS one, 2012 - journals.plos.org
The methylenetetrahydrofolate reductase (MTHFR) gene is one of the main regulatory
enzymes involved in folate metabolism, DNA synthesis and remethylation reactions. The …

Association of the MTHFR 677C> T and 1298A> C polymorphisms and male infertility risk: a meta-analysis

F Aliakbari, F Pouresmaeili, N Eshghifar… - Reproductive Biology …, 2020 - Springer
Background and objectives One of the possible male sterility risk factors are polymorphisms
of Methylenetetrahydrofolate reductase (MTHFR). However, the epidemiologic …

Strong Association of 677 C>T Substitution in the MTHFR Gene with Male Infertility - A Study on an Indian Population and a Meta-Analysis

N Gupta, S Gupta, M Dama, A David, G Khanna… - PloS one, 2011 - journals.plos.org
Background Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme of folate
and methionine metabolism, making it crucial for DNA synthesis and methylation. The …

Significant impact of the MTHFR polymorphisms and haplotypes on male infertility risk

N Gupta, S Sarkar, A David, PK Gangwar, R Gupta… - PloS one, 2013 - journals.plos.org
Background Methylenetetrahydrofolate reductase (MTHFR) converts 5, 10-methylene
tetrahydrofolate to 5-methyl tetrahydrofolate and affects the activity of cellular cycles …

Association of the methylenetetrahydrofolate reductase gene C677T polymorphism with the risk of male infertility: a meta-analysis

X Zhu, Z Liu, M Zhang, R Gong, Y Xu, B Wang - Renal failure, 2016 - Taylor & Francis
Several molecular epidemiological studies have been conducted to examine the association
between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and male …

Methylenetetrahydrofolate reductase C677T polymorphism and the risk of male infertility: a meta‐analysis

W Wu, O Shen, Y Qin, J Lu, X Niu… - … journal of andrology, 2012 - Wiley Online Library
Several molecular epidemiological studies have been conducted to examine the association
between MTHFR C677T polymorphism and male infertility susceptibility, but the results …