Viruses and autoimmune diabetes in rats
JP Mordes, D Zipris, Z Liu, EP Blankenhorn - Diabetes and viruses, 2013 - Springer
The role of viral infection in the pathogenesis of type 1 diabetes in humans remains an open
question. Viruses are variously thought to be causative, preventive, or irrelevant. The rat …
question. Viruses are variously thought to be causative, preventive, or irrelevant. The rat …
Rat Models of Virus-Induced Type 1 Diabetes
JC Needell, D Zipris - Animal Models of Diabetes: Methods and Protocols, 2020 - Springer
Studies performed in humans and animal models have implicated the environment in the
etiology of type 1 diabetes (T1D), but the nature and timing of the interactions triggering β …
etiology of type 1 diabetes (T1D), but the nature and timing of the interactions triggering β …
Virus-induced models for type 1 diabetes in mice
U Christen, MG von Herrath - Diabetes and Viruses, 2012 - Springer
Epidemiological and experimental data strongly suggest that type 1 diabetes occurs as a
detrimental combination of genetic predisposition and environmental triggering factors …
detrimental combination of genetic predisposition and environmental triggering factors …
[引用][C] Does viral infection initiate autoimmunity in type I diabetes?
AK Foulis - Journal of Autoimmunity, 1990 - Elsevier
In Gepts' classical paper of 1965 [1] the concept that insulitis (a chronic inflammatory cell
infiltrate affecting the islets) was pathognomonic of the disease process in Type I diabetes …
infiltrate affecting the islets) was pathognomonic of the disease process in Type I diabetes …
Infection with viruses from several families triggers autoimmune diabetes in LEW. 1WR1 rats: prevention of diabetes by maternal immunization
RS Tirabassi, DL Guberski, EP Blankenhorn, JH Leif… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE The contribution of antecedent viral infection to the development of type 1
diabetes in humans is controversial. Using a newer rat model of the disease, we sought to 1) …
diabetes in humans is controversial. Using a newer rat model of the disease, we sought to 1) …
Induction and prevention of type 1 diabetes mellitus by viruses.
JW Yoon - Diabete & Metabolisme, 1992 - europepmc.org
Genetic factors and environmental factors are thought to be involved in the pathogenesis of
insulin-dependent diabetes mellitus Type 1. Viruses, as one environmental factor, may act …
insulin-dependent diabetes mellitus Type 1. Viruses, as one environmental factor, may act …
Viral pathogenesis of insulin-dependent diabetes mellitus
JW Yoon - Autoimmunity and the Pathogenesis of Diabetes, 1990 - Springer
The familial occurrence of diabetes, or at least, a tendency to develop the disease, has been
long recognized, but the true nature of the genetic mechanisms governing transmission of …
long recognized, but the true nature of the genetic mechanisms governing transmission of …
A new look at viruses in type 1 diabetes
HS Jun, JW Yoon - ILAR journal, 2004 - academic.oup.com
Type 1 diabetes results from the destruction of pancreatic beta cells. Genetic factors are
believed to be a major component for the development of type 1diabetes, but the …
believed to be a major component for the development of type 1diabetes, but the …
How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model
MG von Herrath, J Dockter, MBA Oldstone - Immunity, 1994 - cell.com
We developed two distinct transgenic mouse models in which virus induced insulin-
dependent(type 1) diabetes mellitus (IDDM). In one of these lines, the unique viral transgene …
dependent(type 1) diabetes mellitus (IDDM). In one of these lines, the unique viral transgene …
Immune pathogenesis of diabetes in the nonobese diabetic mouse: an overview
T Hanafusa, S Tarui - The Role of Viruses and the Immune System in …, 1990 - Springer
A considerable amount of evidence suggests that human type 1 or insulin-dependent
diabetes mellitus (IDDM) is a chronic autoimmune disease with a long preclinical period. It is …
diabetes mellitus (IDDM) is a chronic autoimmune disease with a long preclinical period. It is …