The role of viral infection in the pathogenesis of type 1 diabetes in humans remains an open
question. Viruses are variously thought to be causative, preventive, or irrelevant. The rat …

Studies performed in humans and animal models have implicated the environment in the
etiology of type 1 diabetes (T1D), but the nature and timing of the interactions triggering β …

Epidemiological and experimental data strongly suggest that type 1 diabetes occurs as a
detrimental combination of genetic predisposition and environmental triggering factors …

In Gepts' classical paper of 1965 [1] the concept that insulitis (a chronic inflammatory cell
infiltrate affecting the islets) was pathognomonic of the disease process in Type I diabetes …

OBJECTIVE The contribution of antecedent viral infection to the development of type 1
diabetes in humans is controversial. Using a newer rat model of the disease, we sought to 1) …

Genetic factors and environmental factors are thought to be involved in the pathogenesis of
insulin-dependent diabetes mellitus Type 1. Viruses, as one environmental factor, may act …

The familial occurrence of diabetes, or at least, a tendency to develop the disease, has been
long recognized, but the true nature of the genetic mechanisms governing transmission of …

Type 1 diabetes results from the destruction of pancreatic beta cells. Genetic factors are
believed to be a major component for the development of type 1diabetes, but the …

We developed two distinct transgenic mouse models in which virus induced insulin-
dependent(type 1) diabetes mellitus (IDDM). In one of these lines, the unique viral transgene …

A considerable amount of evidence suggests that human type 1 or insulin-dependent
diabetes mellitus (IDDM) is a chronic autoimmune disease with a long preclinical period. It is …