Although many suspected autoimmune diseases are thought to be T cell-mediated, the
response to therapy indicates that depletion of B cells consistently inhibits disease activity. In …

Autoimmune B cells play a major role in mediating tissue damage in multiple sclerosis (MS).
In MS, B cells are believed to cross the blood-brain barrier and undergo stimulation, antigen …

B lymphocytes have essential roles in the autoimmune pathogenesis of multiple sclerosis
(MS). They regulate the autoimmune response and participate in the development of the …

Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system. Once thought to be primarily driven by T cells, B cells are emerging as central …

Multiple sclerosis is a common neurological disorder that represents a significant source of
disability. B cells have recently emerged as a novel therapeutic target for multiple sclerosis …

Summary OTHER ARTICLES PUBLISHED IN THIS MINI-REVIEW SERIES ON B CELL
SUBSETS IN DISEASE Transitional B cells in systemic lupus erythematosus and Sjögren's …

Increasing evidence has suggested that both antibody-dependent and antibody-
independent functions of B cells are involved in multiple sclerosis (MS). The contrasting …

Multiple sclerosis is an autoimmune disease that is caused by the interplay of genetic,
particularly the HLA-DR15 haplotype, and environmental risk factors. How these etiologic …

B cells are essential components of the adaptive immune system and have important roles
in the pathogenesis of several central nervous system (CNS) diseases. Besides producing …

The pathogenic role for B cells in the context of relapsing remitting multiple sclerosis (MS) is
incompletely defined. Although classically considered a T cell-mediated disease, B cell …