The success of ocrelizumab in reducing confirmed disability accumulation in primary
progressive multiple sclerosis (PPMS) via CD20-targeted depletion implicates B cells as …

B cells are thought to play a pathogenic role in multiple sclerosis (MS), an autoimmune
disease affecting the central nervous system (CNS). This idea is supported by the reduction …

Multiple sclerosis is associated with lesions not just in the white matter, but also involving the
cortex. Cortical involvement has been linked to greater disease severity and hence …

Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system (CNS),
traditionally considered a chronic autoimmune attack against the insulating myelin sheaths …

for T-cell help. B-cells internalize and process the antigen–BCR complex, displaying linear
peptides on major histocompatibility complex (MHC) class II. The antigen-primed B-cell …

Memory and naïve B cells are considered to play distinct roles in immune regulation.
However, the roles of memory and naïve B-cell subsets in multiple sclerosis (MS) have not …

There is evidence that B cells are involved in the pathophysiology of many neurological
diseases, either in a causative or contributory role, via production of autoantibodies, cytokine …

The unequivocal success of B-cell–depleting agents in reducing magnetic resonance
imaging and clinical activity in therapeutic trials indicates that B cells play a vital role in …

While over the past decades T cells have been considered key players in the pathogenesis
of multiple sclerosis (MS), it has only recently become evident that B cells have a major …

In spite of keen clinical and neuroscientific interest, the aetiology and immunopathology of
multiple sclerosis (MS) remain to be elucidated. The present work seeks to give insight into …