Although the neurodegeneration occurring in Alzheimer's disease (AD) affects multiple
neurotransmitters, the cholinergic system has received the greatest attention. Acetylcholine …

Cholinergic synapses are ubiquitous in the human central nervous system. Their high
density in the thalamus, striatum, limbic system, and neocortex suggest that cholinergic …

Cognitive deficits in neuropsychiatric disorders, such as Alzheimer's disease (AD), have
been closely related to cholinergic deficits. We have compared different markers of …

Alzheimer's disease (AD) is characterized by progressive cognitive deterioration,
neuropsychological or behavioural disturbances, and eventual elementary neurological …

Cholinergic abnormalities, alongside senile plaques, neurofibrillary tangles, and extensive
neuronal loss, are the major characteristics in Alzheimer's disease (AD). Both nicotinic and …

Deficits in cholinergic function contribute to the pathology of Alzheimer's disease (AD),
affecting cognition, behaviour and activities of daily living. Pharmacological intervention …

The two hallmark lesions of Alzheimer's disease (AD) are extracellular amyloid plaques,
mainly formed by a small peptide called amyloid-β (Aβ), and neurofibrillary tangles, which …

Acetylcholine is critically involved in modulating learning and memory function, which both
decline in neurodegeneration. It remains unclear to what extent structural and functional …

The major components of the cholinergic receptor system of the human brain include
projections from the basal forebrain nuclei, and utilize the two types of receptors that they …

The primary pathology in Alzheimer's disease (DAT) occurs in the basal forebrain
cholinergic system (BFCS), which provides the major cholinergic innervation to the …