[HTML][HTML] Animal models of Parkinson's disease: a gateway to therapeutics?

W Le, P Sayana, J Jankovic - Neurotherapeutics, 2014 - Elsevier
Parkinson's disease (PD) is a progressive, neurodegenerative disorder of unknown etiology,
although a complex interaction between environmental and genetic factors has been …

Genetic mouse models of Parkinson's disease: the state of the art

I Magen, MF Chesselet - Progress in brain research, 2010 - Elsevier
The identification of several mutations causing familial forms of Parkinson's disease (PD)
has led to the creation of multiple lines of mice expressing similar genetic alterations. These …

Genetically engineered animal models of Parkinson's disease: From worm to rodent

LS Breger, MT Fuzzati Armentero - European Journal of …, 2019 - Wiley Online Library
Parkinson's disease (PD) is a progressive neurological disorder characterised by aberrant
accumulation of insoluble proteins, including alpha‐synuclein, and a loss of dopaminergic …

Classic and evolving animal models in Parkinson's disease

T Pingale, GL Gupta - Pharmacology Biochemistry and Behavior, 2020 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disease with motor and non-
motor symptoms. PD is characterized by the degeneration of dopaminergic neurons in the …

Animal models of Parkinson's disease: bridging the gap between disease hallmarks and research questions

A Dovonou, C Bolduc, V Soto Linan, C Gora… - Translational …, 2023 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by
motor and non-motor symptoms. More than 200 years after its first clinical description, PD …

Animal models of Parkinson's disease: An updated overview

P Gubellini, P Kachidian - Revue neurologique, 2015 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder whose etiology,
besides a minority of genetic cases, is still largely unknown. Animal models have contributed …

Genetically engineered mouse models of Parkinson's disease

DM Crabtree, J Zhang - Brain research bulletin, 2012 - Elsevier
Parkinson's disease (PD) is the most common neurodegenerative movement disorder,
affecting more than 1% of the population over age 60. The most common feature of PD is a …

Animal models of Parkinson's disease: are they useful or not?

RA Barker, A Björklund - Journal of Parkinson's Disease, 2020 - content.iospress.com
The use of animal models in Parkinson's disease research has been controversial in terms
of how well they relate to the clinical condition and thus their utility for translating therapies …

Animal models of Parkinson's disease

EA Konnova, M Swanberg - Exon Publications, 2018 - exonpublications.com
Parkinson's disease (PD) is a heterogenous disease with a varying age of onset, symptoms,
and rate of progression. This heterogeneity requires the use of a variety of animal models to …

Limitations of animal models of Parkinson′ s disease

JA Potashkin, SR Blume, NK Runkle - Parkinson's disease, 2011 - Wiley Online Library
Most cases of Parkinson′ s disease (PD) are sporadic. When choosing an animal model for
idiopathic PD, one must consider the extent of similarity or divergence between the …