Morphologic and molecular landscape of pancreatic cancer variants as the basis of new therapeutic strategies for precision oncology

C Bazzichetto, C Luchini, F Conciatori… - International journal of …, 2020 - mdpi.com
To date, pancreatic cancer is still one of the most lethal cancers in the world, mainly due to
the lack of early diagnosis and personalized treatment strategies. In this context, the …

Genomic variations in pancreatic cancer and potential opportunities for development of new approaches for diagnosis and treatment

S Lu, T Ahmed, P Du, Y Wang - International journal of molecular …, 2017 - mdpi.com
Human pancreatic cancer has a very poor prognosis with an overall five-year survival rate of
less than 5% and an average median survival time of six months. This is largely due to …

Pancreatic cancer molecular classifications: From bulk genomics to single cell analysis

L Pompella, G Tirino, A Pappalardo, M Caterino… - International Journal of …, 2020 - mdpi.com
Pancreatic cancer represents one of the most lethal disease worldwide but still orphan of a
molecularly driven therapeutic approach, although many genomic and transcriptomic …

Molecular pathology of pancreatic cancer: from bench-to-bedside translation

V Corbo, G Tortora, A Scarpa - Current Drug Targets, 2012 - ingentaconnect.com
Pancreatic ductal adenocarcinoma (referred here as pancreatic cancer) is a lethal disease
with the worst prognosis among all solid tumors. Surgical resection represents the only hope …

An overview of genetic mutations and epigenetic signatures in the course of pancreatic cancer progression

AA Khan, X Liu, X Yan, M Tahir, S Ali… - Cancer and Metastasis …, 2021 - Springer
Pancreatic cancer (PC) is assumed to be an intimidating and deadly malignancy due to
being the leading cause of cancer-led mortality, predominantly affecting males of older age …

The match between molecular subtypes, histology and microenvironment of pancreatic cancer and its relevance for chemoresistance

J Martinez-Useros, M Martin-Galan, J Garcia-Foncillas - Cancers, 2021 - mdpi.com
Simple Summary Based on the four molecular subtypes of pancreatic cancer described by
Bailey et al. 2016, in the present article we match the molecular, histology and …

[HTML][HTML] Genomic landscapes of pancreatic neoplasia

LD Wood, RH Hruban - Journal of pathology and translational …, 2015 - ncbi.nlm.nih.gov
Pancreatic cancer is a deadly disease with a dismal prognosis. However, recent advances
in sequencing and bioinformatic technology have led to the systematic characterization of …

Pancreatic cancer genomics: insights and opportunities for clinical translation

A Makohon-Moore, JA Brosnan… - Genome medicine, 2013 - Springer
Pancreatic cancer is a highly lethal tumor type for which there are few viable therapeutic
options. It is also caused by the accumulation of mutations in a variety of genes. These …

A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants

J Earl, C Galindo-Pumariño, J Encinas, E Barreto… - …, 2020 - thelancet.com
Background The 5-year survival rate of patients with pancreatic ductal adenocarcinoma
(PDAC) is around 5% due to the fact that the majority of patients present with advanced …

Molecular signature of pancreatic adenocarcinoma: an insight from genotype to phenotype and challenges for targeted therapy

IH Sahin, CA Iacobuzio-Donahue… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Pancreatic adenocarcinoma remains one of the most clinically challenging
cancers despite an in-depth characterization of the molecular underpinnings and biology of …