Background Ifosfamide (IFO) is an alkylating agent administered against different types of
malignancies. Several cases of renal injury and serum electrolytes disturbances have been …

Ifosfamide (IFO) kidney damage is an important organ toxicity in children and adults
undergoing chemotherapy. Previous evidence has shown that IFO toxic metabolites such as …

Maleic acid (MA)-induced nephropathy that is characterized by proteinuria, glycosuria,
phosphaturia and a deficient urinary acidification and concentration. Sulforaphane (SF) is an …

Mitochondrial dysfunction is a basic mechanism leading to drug nephrotoxicity.
Replacement of defective mitochondria with freshly isolated mitochondria is potentially a …

Background: Some researches revealed that mitochondrial dysfunction is associated with
various kidney injury. However, the role of mitochondrial dysfunction in the pathogenesis of …

Colistin (COL) belongs to the polymixin class of antibiotics used as the last line antibiotic
against drug-resistant infections. However, nephrotoxicity is the major deleterious and dose …

Adriamycin (ADR) is commonly used for many solid tumor treatments. Its clinical utility is,
however, largely limited by the adverse reactions, are known to be nephrotoxic. The …

Chronic kidney disease (CKD) is commonly characterized by proteinuria and leads to
progressive glomerulosclerosis and tubulointerstitial fibrosis. Accumulating evidence …

Objective. Mitochondrial damage contributes to extracellular matrix (ECM) deposition and
renal fibrosis. In this study, we aimed (1) to investigate whether fluorofenidone (AKF‐PD) …

Ifosfamide (IFO) is used for treating childhood solid tumors, but its use is limited by its
adverse effects on kidneys. Morin may be used to prevent nephrotoxic and other side effects …