Response of mesenchymal stem cells to surface topography of scaffolds and the underlying mechanisms

L Xiao, Y Sun, L Liao, X Su - Journal of Materials Chemistry B, 2023 - pubs.rsc.org
Mesenchymal stem/stromal cells (MSCs) serve as essential components of regenerative
medicine. Their destiny is influenced by the interaction of the cells with the external …

Topography: a biophysical approach to direct the fate of mesenchymal stem cells in tissue engineering applications

X Cun, L Hosta-Rigau - Nanomaterials, 2020 - mdpi.com
Tissue engineering is a promising strategy to treat tissue and organ loss or damage caused
by injury or disease. During the past two decades, mesenchymal stem cells (MSCs) have …

[HTML][HTML] Effects of nanotopography on stem cell phenotypes

R Ravichandran, S Liao, CCH Ng, CK Chan… - World journal of stem …, 2009 - ncbi.nlm.nih.gov
Stem cells are unspecialized cells that can self renew indefinitely and differentiate into
several somatic cells given the correct environmental cues. In the stem cell niche, stem cell …

Engineered Nano–Bio Interfaces for Stem Cell Therapy

A Umer, MD Ghouri, T Muyizere, RM Aqib… - Precision …, 2023 - ACS Publications
Engineered nanomaterials (ENMs) with different topographies provide effective nano–bio
interfaces for controlling the differentiation of stem cells. The interaction of stem cells with …

The superficial mechanical and physical properties of matrix microenvironment as stem cell fate regulator

M Shahrousvand, GMM Sadeghi… - Advanced Surfaces for …, 2016 - Wiley Online Library
All of the cells' interactions are done through their surfaces. So, whatever associated with
cell surface can affect its behavior. Stem cells show more significant sensitivity to surface …

Influence of surface topographical cues on the differentiation of mesenchymal stem cells in vitro

K Metavarayuth, P Sitasuwan, X Zhao… - ACS Biomaterials …, 2016 - ACS Publications
Adult stem cell research has been advanced in recent years because of the cells' attractive
abilities of self-renewal and differentiation. Topography of materials is one of the key …

Nanostructured scaffold as a determinant of stem cell fate

L Krishna, K Dhamodaran, C Jayadev… - Stem Cell Research & …, 2016 - Springer
The functionality of stem cells is tightly regulated by cues from the niche, comprising both
intrinsic and extrinsic cell signals. Besides chemical and growth factors, biophysical signals …

The effect of nanostructured surfaces on stem cell fate

D Schipper, P Babczyk, F Elsayed, SE Klein… - Nanostructures for novel …, 2017 - Elsevier
The ability of stem cells to self-renew and differentiate into multiple lineages has made them
attractive candidates for therapeutic interventions. Adult stem cells are a promising source …

[HTML][HTML] An update of nanotopographical surfaces in modulating stem cell fate: a narrative review

S Cao, Q Yuan - Biomaterials Translational, 2022 - ncbi.nlm.nih.gov
Stem cells have been one of the ideal sources for tissue regeneration owing to their
capability of self-renewal and differentiation. In vivo, the extracellular microenvironment …

Engineering nanoscale stem cell niche: direct stem cell behavior at cell–matrix interface

Y Zhang, A Gordon, W Qian… - Advanced healthcare …, 2015 - Wiley Online Library
Biophysical cues on the extracellular matrix (ECM) have proven to be significant regulators
of stem cell behavior and evolution. Understanding the interplay of these cells and their …