Cancers arise through the process of somatic evolution fueled by the inception of somatic
mutations. We lack a complete understanding of the sources of these somatic mutations …

The intersection of the microbiota and cancer and the mechanisms that define these
interactions are a fascinating, rapidly evolving area of cancer biology and therapeutics. Here …

Aetiogenesis of cancer has not been fully determined. Recent advances have clearly
defined a role for microenvironmental factors in cancer progression and initiation; in this …

Cancer arises from the acquisition of multiple genetic and epigenetic changes in host cells
over the span of many years, promoting oncogenic traits and carcinogenesis. Most cancers …

A host's microbiota may increase, diminish, or have no effect at all on cancer susceptibility.
Assigning causal roles in cancer to specific microbes and microbiotas, unraveling host …

Gene–environment interactions underlie cancer susceptibility and progression. Yet, we still
have limited knowledge of which environmental factors are important and how they function …

Complex and intricate circuitries regulate cellular proliferation, survival, and growth, and
alterations of this network through genetic and epigenetic events result in aberrant cellular …

Both the number of cells and the collective genome of the gut microbiota outnumber their
mammalian hosts, and the metabolic and physiological interactions of the gut microbiota …

Over the years, cancer has been affecting the lives of many people globally and it has
become one of the most studied diseases. Despite the efforts to understand the cell …

During life, the DNA of our cells is continuously exposed to external damaging processes.
Despite the activity of various repair mechanisms, DNA damage eventually results in the …