Background/Aims: Many clinical and experimental studies have shown that treatment with
statins could prevent myocardial hypertrophy and remodeling induced by hypertension and …

Previous evidences suggested that atorvastatin not only reduced blood lipids but also
reduced myocardial hypertrophy and remodeling. And it was reported that C/EBPβ …

Atorvastatin is employed as a lipid lowering agent and its heart protective effect has been
recently reported as well. However, the mechanism of atorvastatin in attenuating cardiac …

Left ventricular hypertrophy (LVH) is a pathological characteristic shared by distinct heart
disorders. Atorvastatin is employed as a lipid lowering agent and its heart protection effect …

Background Simvastatin, an HMG-CoA reductase inhibitor, has been reported to exert
multiple protective effects on the cardiovascular system. However, the molecular mechanism …

The present study was designed to determine whether atorvastatin reduced hypertension-
induced cardiac remodeling and whether these effects involved Protein Kinase D (PKD) and …

This study was designed to investigate whether atorvastatin has a beneficial effect on left
ventricular (LV) remodeling in spontaneously hypertensive rats (SHR), and then explore the …

Background: A substantial proportion of patients with heart failure have a normal ejection
fraction and diastolic dysfunction. However, there are few data available to guide the therapy …

Purpose. To investigate whether the role of atorvastatin in suppression of cardiac
hypertrophy is potentially associated with the change of peroxisome proliferator-activated …

End‐stage hypertensive heart disease is an increasing cause of cardiac mortality. Therefore,
the current study focused on the cardiac remodelling from hypertrophy to fibrosis in old …