Background An overdose of acetaminophen (APAP), the main cause of acute liver failure
(ALF), induces oxidative stress that ultimately causes mitochondrial impairment and …

Background Acetaminophen (APAP) overdose-induced acute liver failure (ALF) is mainly
resulted from uncontrolled oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2) …

Acetaminophen (APAP) toxicity leads to severe acute liver injury (ALI) by inducing excessive
oxidative stress, inflammatory response, and hepatocyte apoptosis. Imperatorin (IMP) is a …

Acetaminophen (APAP) overdose accounts for the majority of acute liver failure cases, and
oxidative stress plays a key role in its toxic effects. Esculentoside A (EsA) has anti-oxidant …

Acetaminophen (APAP)-induced liver injury is a common hepatic disease resulting from
drug abuse. Few targeted treatments are available clinically nowadays. The flower bud of …

Farrerol has been shown to have antioxidative potential via Nrf2 activation, which in turn is
involved in the prevention of hepatotoxicity. The purpose of the current study was to explore …

Puerarin (Pue) is a kind of isoflavone compound extracted from Pueraria lobata, which has
significant antioxidant activity. Excessive use of acetaminophen (APAP) can cause oxidative …

Cardamonin (CD), a naturally occurring chalcone derived from the Alpinia species, has
been shown to exert antioxidant and anti-inflammatory activity, but its role in the prevention …

Mitochondrial dysfunction and oxidative stress are considered to be key events in
acetaminophen (APAP)-induced acute liver injury. Mitochondrial quality control, including …

Severe acetaminophen (APAP)‐induced hepatic damage is the second most common
cause for hepatic transplantation. Clinically, hepatic damage caused by APAP is treated …