Recombinant subunit vaccines for soil-transmitted helminths

JB Noon, RV Aroian - Parasitology, 2017 - cambridge.org
Soil-transmitted helminths (STHs) collectively infect one fourth of all human beings, and the
majority of livestock in the developing world. These gastrointestinal nematodes are the most …

Vaccination against helminth parasite infections

JP Hewitson, RM Maizels - Expert review of vaccines, 2014 - Taylor & Francis
Helminth parasites infect over one fourth of the human population and are highly prevalent
in livestock worldwide. In model systems, parasites are strongly immunomodulatory, but the …

Recombinant expression systems: the obstacle to helminth vaccines?

P Geldhof, V De Maere, J Vercruysse… - Trends in parasitology, 2007 - cell.com
The need for alternative ways to control helminth parasites has in recent years led to a boost
in vaccination experiments with recombinant antigens. Despite the use of different …

[HTML][HTML] Soil-transmitted helminth vaccines: are we getting closer?

A Zawawi, KJ Else - Frontiers in immunology, 2020 - frontiersin.org
Parasitic helminths infect over one-fourth of the human population resulting in significant
morbidity, and in some cases, death in endemic countries. Despite mass drug administration …

[HTML][HTML] Promising technologies in the field of helminth vaccines

DJ Perera, M Ndao - Frontiers in immunology, 2021 - frontiersin.org
Helminths contribute a larger global burden of disease than both malaria and tuberculosis.
These eukaryotes have caused human infections since before our earliest recorded history …

Soil-transmitted helminthic vaccines: Where are we now?

MTJ Wong, NS Anuar, R Noordin, GJ Tye - Acta tropica, 2023 - Elsevier
It has been tested and proven that vaccination is still the best strategy to combat infectious
diseases. However, to date, there are still no vaccines against human soil-transmitted …

[HTML][HTML] Lessons along the critical path: developing vaccines against human helminths

DJ Diemert, ME Bottazzi, J Plieskatt, PJ Hotez… - Trends in …, 2018 - cell.com
Helminthic parasites are important targets for vaccine research as they infect an estimated 1
billion people worldwide. Despite significant progress in the discovery of defined antigens …

Identifying novel candidates and configurations for human helminth vaccines

RM Maizels - Expert Review of Vaccines, 2021 - Taylor & Francis
Introduction: Human infections with helminth worm parasites are extraordinarily prevalent
across tropical and subtropical parts of the world, and control relies primarily on drugs that …

[HTML][HTML] How to train your myeloid cells: a way forward for helminth vaccines?

R Doolan, N Putananickal, L Tritten… - Frontiers in …, 2023 - frontiersin.org
Soil-transmitted helminths affect approximately 1.5 billion people worldwide. However, as no
vaccine is currently available for humans, the current strategy for elimination as a public …

Advances in helminth immunology: optimism for future vaccine design?

NL Harris - Trends in parasitology, 2011 - cell.com
Intestinal helminths infect approximately 2 billion people worldwide. Worm burdens correlate
with disease morbidity and children generally harbor the largest numbers. The majority of …