Tissue engineering provides the opportunity to construct biomaterial scaffolds to replace or
regenerate damaged or injured tissue or organ. However, the implantation-mediated injury …

Implantation of cell-laden scaffolds is a promising strategy for regenerating tissue that has
been damaged due to injury or disease. However, the act of implantation initiates an acute …

The compatibility of biomaterials is critical to their structural and biological function in
medical applications. The immune system is the first responder to tissue trauma and to a …

Awide range of implanted biomaterials, tissue en-gineered scaffolds, and devices interact
with the immune system via complex and not well-understood mechanisms. This is due, in …

Objectives Biomaterials are routinely used in clinical applications. A key to the clinical
success of implanted biomaterials is not eliciting detrimental immune responses. In this …

Biomaterials are widely used to produce devices for regenerative medicine. After its
implantation, an interaction between the host immune system and the implanted biomaterial …

As the global health burden of chronic disease increases, end-stage organ failure has
become a costly and intractable problem. De novo organ creation is one of the long-term …

The foreign body reaction composed of macrophages and foreign body giant cells is the end-
stage response of the inflammatory and wound healing responses following implantation of …

Tissue engineering scaffolds have emerged as a powerful tool within regenerative medicine.
These materials are being designed to create environments that promote regeneration …

Recent research in the vaccine and immunotherapy fields has revealed that biomaterials
have the ability to activate immune pathways, even in the absence of other immune …