[HTML][HTML] Identification of critical elements for regulation of inorganic pyrophosphatase (PPA1) in MCF7 breast cancer cells
DR Mishra, S Chaudhary, BM Krishna, SK Mishra - PLoS One, 2015 - journals.plos.org
Cytosolic inorganic pyrophosphatase plays an important role in the cellular metabolism by
hydrolyzing inorganic pyrophosphate (PPi) formed as a by-product of various metabolic …
hydrolyzing inorganic pyrophosphate (PPi) formed as a by-product of various metabolic …
[HTML][HTML] PPA1, an energy metabolism initiator, plays an important role in the progression of malignant tumors
S Wang, J Wei, S Li, Y Luo, Y Li, X Wang… - Frontiers in …, 2022 - frontiersin.org
Inorganic pyrophosphatase (PPA1) encoded by PPA1 gene belongs to Soluble
Pyrophosphatases (PPase) family and is expressed widely in various tissues of Homo …
Pyrophosphatases (PPase) family and is expressed widely in various tissues of Homo …
[HTML][HTML] PPA1 promotes breast cancer proliferation and metastasis through PI3K/AKT/GSK3β signaling pathway
C Guo, S Li, A Liang, M Cui, Y Lou… - Frontiers in Cell and …, 2021 - frontiersin.org
Breast cancer is the most common malignancy among women. Inorganic pyrophosphatase
1 (PPA1) is a multifunctional protein involved in the development of several tumors …
1 (PPA1) is a multifunctional protein involved in the development of several tumors …
Pyrophosphatase overexpression is associated with cell migration, invasion, and poor prognosis in gastric cancer
SH Jeong, GH Ko, YH Cho, YJ Lee, BI Cho, WS Ha… - Tumor Biology, 2012 - Springer
Inorganic pyrophosphatase (PPase) catalyzes the hydrolysis of pyrophosphate to form
orthophosphate. Pyrophosphate can substitute for ATP under certain circumstances. We …
orthophosphate. Pyrophosphate can substitute for ATP under certain circumstances. We …
Inorganic pyrophosphatase 1 activates the phosphatidylinositol 3-kinase/Akt signaling to promote tumorigenicity and stemness properties in colorectal cancer
T Niu, J Zhu, L Dong, P Yuan, L Zhang, D Liu - Cellular Signalling, 2023 - Elsevier
Colorectal cancer (CRC) is a common malignant tumor of the human digestive tract.
Inorganic pyrophosphatase 1 (PPA1) plays an imperative role in the advancement of …
Inorganic pyrophosphatase 1 (PPA1) plays an imperative role in the advancement of …
[HTML][HTML] Inorganic pyrophosphatase (PPA1) is a negative prognostic marker for human gastric cancer
Inorganic pyrophosphatase (PPA1) is an enzyme which has been found to be upregulated
in various tumors, yet its profile in gastrointestinal cancers has not systemically investigated …
in various tumors, yet its profile in gastrointestinal cancers has not systemically investigated …
[HTML][HTML] PPA1 promotes NSCLC progression via a JNK-and TP53-dependent manner
D Luo, D Liu, W Shi, H Jiang, W Liu, X Zhang, Y Bao… - Oncogenesis, 2019 - nature.com
Inorganic pyrophosphatase (PPA1) promotes tumor progression in several tumor types.
However, the underlying mechanism remains elusive. Here, we disclosed that PPA1 …
However, the underlying mechanism remains elusive. Here, we disclosed that PPA1 …
[HTML][HTML] Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/β-catenin signaling pathway
H Niu, W Zhou, Y Xu, Z Yin, W Shen, Z Ye, Y Liu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Inorganic pyrophosphatase (PPA1) activity is a key determinant of cellular inorganic
pyrophosphate levels, and its expression is correlated with growth of several solid tumors …
pyrophosphate levels, and its expression is correlated with growth of several solid tumors …
Crystallographic and modeling study of the human inorganic pyrophosphatase 1: A potential anti‐cancer drug target
Inorganic pyrophosphatases (PPases) catalyze the hydrolysis of pyrophosphate to
phosphates. PPases play essential roles in growth and development, and are found in all …
phosphates. PPases play essential roles in growth and development, and are found in all …
[HTML][HTML] PPA1 regulates tumor malignant potential and clinical outcome of colon adenocarcinoma through JNK pathways
P Wang, Y Zhou, Q Mei, J Zhao, L Huang, Q Fu - Oncotarget, 2017 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) represents one of the most prevalent malignancies and the third
leading cause of cancer death worldwide. Inorganic pyrophosphatase (PPA1) is an enzyme …
leading cause of cancer death worldwide. Inorganic pyrophosphatase (PPA1) is an enzyme …