Clopidogrel with aspirin in High-risk patients with Acute Non-disabling Cerebrovascular Events II (CHANCE-2): rationale and design of a multicentre randomised trial

Y Wang, C Johnston, PM Bath, X Meng… - Stroke and vascular …, 2021 - svn.bmj.com
Background In patients with a minor ischaemic stroke or transient ischaemic attack (TIA),
separate trials have shown that dual antiplatelet therapy with clopidogrel plus aspirin …

[PDF][PDF] Outcomes associated with clopidogrel-aspirin use in minor stroke or transient ischemic attack: a pooled analysis of Clopidogrel in High-Risk Patients With Acute …

Y Pan, JJ Elm, H Li, JD Easton, Y Wang… - JAMA …, 2019 - jamanetwork.com
Importance Dual antiplatelet therapy with clopidogrel and aspirin is effective for secondary
prevention after minor ischemic stroke or transient ischemic attack (TIA). Uncertainties …

Risks and benefits of clopidogrel–aspirin in minor stroke or TIA: time course analysis of CHANCE

Y Pan, J Jing, W Chen, X Meng, H Li, X Zhao, L Liu… - Neurology, 2017 - AAN Enterprises
Objective: To investigate the short-term time course risks and benefits of clopidogrel with
aspirin in minor ischemic stroke or TIA. Methods: Data were derived from the Clopidogrel in …

Effect of clopidogrel on the rate and functional severity of stroke among high vascular risk patients: a prespecified substudy of the Clopidogrel for High …

GJ Hankey, W Hacke, JD Easton, SC Johnston, JL Mas… - Stroke, 2010 - Am Heart Assoc
Background and Purpose—Disabling stroke is costly and considered by some patients a
fate worse than death. We aimed to determine whether clopidogrel reduces the rate and …

[HTML][HTML] Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA

SC Johnston, JD Easton, M Farrant… - … England Journal of …, 2018 - Mass Medical Soc
Background Combination antiplatelet therapy with clopidogrel and aspirin may reduce the
rate of recurrent stroke during the first 3 months after a minor ischemic stroke or transient …

Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double …

HC Diener, J Bogousslavsky, LM Brass, C Cimminiello… - The Lancet, 2004 - thelancet.com
Background Clopidogrel was superior to aspirin in patients with previous manifestations of
atherothrombotic disease in the CAPRIE study and its benefit was amplified in some high …

[HTML][HTML] Benefits and risks of clopidogrel vs. aspirin monotherapy after recent ischemic stroke: a systematic review and meta-analysis

M Paciaroni, B Ince, B Hu, JS Jeng, K Kutluk… - Cardiovascular …, 2019 - hindawi.com
Aim. Though combination of clopidogrel added to aspirin has been compared to aspirin
alone in patients with stroke or transient ischemic attack, limited data exists on the relative …

Is clopidogrel better than aspirin following breakthrough strokes while on aspirin? A retrospective cohort study

M Lee, YL Wu, JL Saver, HC Lee, JD Lee, KC Chang… - Bmj Open, 2014 - bmjopen.bmj.com
Objective There is insufficient evidence on which to base a recommendation for optimal
antiplatelet therapy following a stroke while on aspirin. The objective was to compare …

Rationale and design of a randomized, double-blind trial comparing the effects of a 3-month clopidogrel-aspirin regimen versus aspirin alone for the treatment of high …

Y Wang, SC Johnston, CHANCE investigators - American heart journal, 2010 - Elsevier
BACKGROUND: Acute nondisabling cerebrovascular events are common and often portend
a disabling stroke. Aspirin is the only antiplatelet agent to have been studied in patients …

Time course for benefit and risk of clopidogrel and aspirin after acute transient ischemic attack and minor ischemic stroke: a secondary analysis from the POINT …

SC Johnston, JJ Elm, JD Easton, M Farrant… - Circulation, 2019 - Am Heart Assoc
Background: In patients with acute minor ischemic stroke or high-risk transient ischemic
attack enrolled in the POINT trial (Platelet-Oriented Inhibition in New TIA and Minor Ischemic …