Unresolved issues in left ventricular postischemic remodeling and progression to heart failure

E Gronda, S Sacchi, G Benincasa… - Journal of …, 2019 - journals.lww.com
In the past decades, myocardial infarction periacute mortality markedly declined since
coronary reperfusion therapy has been adopted. Despite immediate benefits of coronary …

Postinfarction left ventricular remodeling: a pathophysiological and therapeutic review

Z Yousef, SR Redwood, MS Marber - Cardiovascular drugs and therapy, 2000 - Springer
Over the last 50 years, studies investigating the pathogenesis of left ventricular dysfunction
have resulted in many potential therapeutic targets being identified and novel classes of …

Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies

S Frantz, MJ Hundertmark… - European heart …, 2022 - academic.oup.com
Most patients survive acute myocardial infarction (MI). Yet this encouraging development
has certain drawbacks: heart failure (HF) prevalence is increasing and patients affected tend …

Left ventricular remodeling in the post-infarction heart: a review of cellular, molecular mechanisms, and therapeutic modalities

JJ Gajarsa, RA Kloner - Heart failure reviews, 2011 - Springer
As more patients survive myocardial infarctions, the incidence of heart failure increases.
After an infarction, the human heart undergoes a series of structural changes, which are …

Left ventricular remodeling after myocardial infarction: from physiopathology to treatment

SA Leancă, D Crișu, AO Petriș, I Afrăsânie, A Genes… - Life, 2022 - mdpi.com
Myocardial infarction (MI) is the leading cause of death and morbidity worldwide, with an
incidence relatively high in developed countries and rapidly growing in developing …

Postinfarction left ventricular remodelling: where are the theories and trials leading us?

ZR Yousef, SR Redwood, MS Marber - Heart, 2000 - heart.bmj.com
While mortality from overt ischaemic heart disease is falling, that from heart failure is
increasing and reaching epidemic proportions. 1 Although an aging population is partly …

Temporal cardiac remodeling post-myocardial infarction: dynamics and prognostic implications in personalized medicine

R Altara, M Manca, R Sabra, AA Eid, GW Booz… - Heart failure …, 2016 - Springer
Despite dramatic improvements in short-term mortality rates following myocardial infarction
(MI), long-term survival for MI patients who progress to heart failure remains poor. MI occurs …

Mechanisms of postinfarct left ventricular remodeling

BA French, CM Kramer - Drug Discovery Today: Disease Mechanisms, 2007 - Elsevier
Heart failure secondary to myocardial infarction (MI) remains a major source of morbidity
and mortality. Long-term outcome after MI can be largely be defined in terms of its impact on …

Ischemic cardiomyopathy and heart failure after acute myocardial infarction

MG Del Buono, F Moroni, RA Montone… - Current Cardiology …, 2022 - Springer
Abstract Purpose of Review Ischemic cardiomyopathy refers to systolic left ventricular
dysfunction in the setting of obstructive coronary artery disease and represents the most …

Using extracellular matrix proteomics to understand left ventricular remodeling

ML Lindsey, ST Weintraub… - Circulation: Cardiovascular …, 2012 - Am Heart Assoc
Survival following myocardial infarction has improved substantially over the last 40 years;
however, the incidence of subsequent congestive heart failure has increased dramatically …