[HTML][HTML] Early resistance of non-virulent mycobacterial infection in C57BL/6 mice is associated with rapid up-regulation of antimicrobial cathelicidin Camp
L Adam, M López-González, A Björk… - Frontiers in …, 2018 - frontiersin.org
Early clearance of tuberculosis is the successful eradication of inhaled bacteria before the
development of an adaptive immune response. We previously showed, by utilizing a non …
development of an adaptive immune response. We previously showed, by utilizing a non …
[HTML][HTML] Early innate immunity determines outcome of Mycobacterium tuberculosis pulmonary infection in rabbits
Background Pulmonary infection of humans by Mycobacterium tuberculosis (Mtb), the
causative agent of tuberculosis (TB), results in active disease in 5-10% of individuals, while …
causative agent of tuberculosis (TB), results in active disease in 5-10% of individuals, while …
[HTML][HTML] Gr1int/high cells dominate the early phagocyte response to mycobacterial lung infection in mice
BM Ryder, SK Sandford, KM Manners… - Frontiers in …, 2019 - frontiersin.org
Lung infection by Mycobacterium tuberculosis is characterized by chronic infection of lung-
resident macrophages, long considered to be the primary hosts and determinants of the …
resident macrophages, long considered to be the primary hosts and determinants of the …
Endogenous cathelicidin production limits inflammation and protective immunity to Mycobacterium avium in mice
The production of antimicrobial peptides, such as the cathelicidins, plays a prominent role in
the innate immune response against microbial pathogens. Cathelicidins are widely …
the innate immune response against microbial pathogens. Cathelicidins are widely …
Bacterial subversion of cAMP signalling inhibits cathelicidin expression, which is required for innate resistance to Mycobacterium tuberculosis
Antimicrobial peptides such as cathelicidins are important components of innate immune
defence against inhaled microorganisms, and have shown antimicrobial activity against …
defence against inhaled microorganisms, and have shown antimicrobial activity against …
Bacterial Strain–Dependent Dissociation of Cell Recruitment and Cell-to-Cell Spread in Early M. tuberculosis Infection
BS Zha, L Desvignes, TJ Fergus, A Cornelius… - Mbio, 2022 - Am Soc Microbiol
In the initial stage of respiratory infection, Mycobacterium tuberculosis traverses from
alveolar macrophages to phenotypically diverse monocyte-derived phagocytes and …
alveolar macrophages to phenotypically diverse monocyte-derived phagocytes and …
Cathelicidin is involved in the intracellular killing of mycobacteria in macrophages
Macrophages have been shown to kill Mycobacterium tuberculosis through the action of the
antimicrobial peptide cathelicidin (CAMP), whose expression was shown to be induced by 1 …
antimicrobial peptide cathelicidin (CAMP), whose expression was shown to be induced by 1 …
Cathelicidin-related antimicrobial peptide is required for effective lung mucosal immunity in Gram-negative bacterial pneumonia
MA Kovach, MN Ballinger, MW Newstead… - The Journal of …, 2012 - journals.aai.org
Cathelicidins are a family of endogenous antimicrobial peptides that exert diverse immune
functions, including both direct bacterial killing and immunomodulatory effects. In this study …
functions, including both direct bacterial killing and immunomodulatory effects. In this study …
[HTML][HTML] Differential and Site Specific Impact of B Cells in the Protective Immune Response to Mycobacterium tuberculosis in the Mouse
E Torrado, JJ Fountain, RT Robinson, CA Martino… - PloS one, 2013 - journals.plos.org
Cell-mediated immune responses are known to be critical for control of mycobacterial
infections whereas the role of B cells and humoral immunity is unclear. B cells can modulate …
infections whereas the role of B cells and humoral immunity is unclear. B cells can modulate …
[HTML][HTML] Characterizing the BCG Induced Macrophage and Neutrophil Mechanisms for Defense Against Mycobacterium tuberculosis
TE Bickett, J McLean, E Creissen, L Izzo… - Frontiers in …, 2020 - frontiersin.org
The live attenuated Mycobacterium bovis strain, Bacille Calmette Guérin (BCG) is a potent
innate immune stimulator. In the C57BL/6 mouse model of tuberculosis, BCG vaccination …
innate immune stimulator. In the C57BL/6 mouse model of tuberculosis, BCG vaccination …