Early clearance of tuberculosis is the successful eradication of inhaled bacteria before the
development of an adaptive immune response. We previously showed, by utilizing a non …

Background Pulmonary infection of humans by Mycobacterium tuberculosis (Mtb), the
causative agent of tuberculosis (TB), results in active disease in 5-10% of individuals, while …

Lung infection by Mycobacterium tuberculosis is characterized by chronic infection of lung-
resident macrophages, long considered to be the primary hosts and determinants of the …

The production of antimicrobial peptides, such as the cathelicidins, plays a prominent role in
the innate immune response against microbial pathogens. Cathelicidins are widely …

Antimicrobial peptides such as cathelicidins are important components of innate immune
defence against inhaled microorganisms, and have shown antimicrobial activity against …

In the initial stage of respiratory infection, Mycobacterium tuberculosis traverses from
alveolar macrophages to phenotypically diverse monocyte-derived phagocytes and …

Macrophages have been shown to kill Mycobacterium tuberculosis through the action of the
antimicrobial peptide cathelicidin (CAMP), whose expression was shown to be induced by 1 …

Cathelicidins are a family of endogenous antimicrobial peptides that exert diverse immune
functions, including both direct bacterial killing and immunomodulatory effects. In this study …

Cell-mediated immune responses are known to be critical for control of mycobacterial
infections whereas the role of B cells and humoral immunity is unclear. B cells can modulate …

The live attenuated Mycobacterium bovis strain, Bacille Calmette Guérin (BCG) is a potent
innate immune stimulator. In the C57BL/6 mouse model of tuberculosis, BCG vaccination …