Acinetobacter baumannii is known for its multidrug antibiotic resistance. New approaches to
treating drug-resistant bacterial infections are urgently required. Cathelicidin-related …

We developed an approach for substantial attenuation of Mycobacterium tuberculosis by
prolonged culturing under gradually acidifying conditions. Bacteria subjected to acidification …

The innate immune system provides the first response to infection and is now recognized to
be partially pathogen-specific. Mycobacterium tuberculosis (MTB) is able to subvert the …

Mycobacterium bovis bacille Calmette-Guérin (BCG) is the most widely used live attenuated
vaccine. However, the correlates of protection and waning of its immunity against …

Background Some individuals, even when heavily exposed to an infectious tuberculosis
patient, develop neither active nor latent tuberculosis infection (LTBI). This 'early …

Growing evidence suggests the outcome of Mycobacterium tuberculosis infection is
established rapidly after exposure, but how the current tuberculosis vaccine, bacillus …

An efficacious vaccine against adult tuberculosis (TB) remains elusive. Progress is
hampered by an incomplete understanding of the immune mechanisms that protect against …

The immune mechanisms underlying delayed induction of T h1‐type immunity in the lungs
following pulmonary mycobacterial infection remain poorly understood. We have herein …

Alveolar macrophages (AMs) play a critical role during Mycobacterium tuberculosis (Mtb)
infection as the first cells in the lung to encounter bacteria. We previously showed that AMs …

Tuberculosis (TB) is caused by the intracellular bacteria Mycobacterium tuberculosis, and
kills more than 1.5 million people every year worldwide. Immunity to TB is associated with …