Introduction During infection, bone marrow (BM) hematopoiesis is reprogrammed toward
myeloid cell production, a mechanism named emergency myelopoiesis. In addition to …

Tuberculosis (TB), caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is
a global health threat. Targeting host pathways that modulate protective or harmful …

The functional role of CD8+ lymphocytes in tuberculosis remains poorly understood. We
depleted innate and/or adaptive CD8+ lymphocytes in macaques and showed that loss of all …

Granulocyte recruitment to the pulmonary compartment is a hallmark of progressive
tuberculosis (TB). This process is well-documented to promote immunopathology, but can …

Tuberculosis (TB) is a highly contagious infection and devastating chronic disease, causing
10.4 million new infections and 1.8 million deaths every year globally. Efforts to control and …

Little is known about the activation programme induced in alveolar macrophages upon
phagocytosis of mycobacteria and the concomitant mononuclear phagocyte migratory …

We characterize the breadth, function and phenotype of innate and adaptive cellular
responses in a prevention of Mycobacterium tuberculosis infection trial. Responses are …

Despite international control programmes, the global burden of tuberculosis remains
enormous. Efforts to discover novel drugs have largely focused on targeting the bacterium …

Infection with Mycobacterium tuberculosis causes the illness tuberculosis with an annual
mortality of≈ 2 million. Understanding the nature of the host-pathogen interactions at …

Mycobacterium tuberculosis is a highly successful human pathogen that primarily resides in
host phagocytes, such as macrophages and dendritic cells (DCs), and interferes with their …