Interleukin-1β (IL-1β), a product of the NLRP3 inflammasome, modulates cardiac contractility
and diastolic function. We proposed that OLT1177®(dapansutrile), a novel NLRP3 inhibitor …

Background: Activation of the NLRP3 inflammasome is a primary driver of sterile
inflammation in response to myocardial ischemia reperfusion. Pharmacologic inhibitors of …

Background: Sterile inflammation resulting from myocardial injury activates the NLRP3
inflammasome and amplifies the inflammatory response mediating further damage …

Aims Myocardial infarction (MI) triggers an intense inflammatory response that is associated
with infarct expansion and is detrimental for cardiac function. Interleukin (IL)-1β and IL-18 …

Abstract Background/Aims. Early inflammatory responses after myocardial infarction (MI) are
likely to increase myocardial fibrosis and subsequent cardiac remodeling. MCC950, a …

NLRP3-inflammasome-mediated signaling is thought to significantly contribute to the extent
of myocardial damage after myocardial infarction (MI). The purpose of this study was to …

Background Successful reperfusion is the most effective strategy to reduce ischemic injury in
acute myocardial infarction (AMI). Ischemic injury, however, also triggers a secondary …

An accumulating body of evidence indicates that inflammation plays a crucial role in the
pathophysiology of myocardial infarction (MI). Nucleotide-binding oligomerization domain …

The NLRP3 inflammasome is an intracellular, multimeric protein complex that initiates a
potent inflammatory response to danger signals. After acute myocardial infarction, NLRP3 …

New findings• What is the central question of this study? Heart failure is associated with
persistent sterile inflammation that worsens disease severity; however, the molecular …