Background: Mechanical stress on the heart, such as high blood pressure, initiates
inflammation and causes hypertrophic heart disease. However, the regulatory mechanism of …

Acute myocardial infarction (AMI) is associated with the induction of a sterile inflammatory
response that leads to further injury. The NACHT, leucine-rich repeat, and pyrin domain …

The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is a macromolecular structure responsible for the inflammatory …

Studies have shown that Nod-like receptor protein (NLRP) 3 inflammasome activation
contributes to myocardial ischemia/reperfusion (I/R) injury. However, the role and …

We have recently read with great interest the report by Toldo and co-workers [1] concerning
“Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial …

The heart is extremely sensitive to ischaemic injury. During an acute myocardial infarction
(AMI) event, the injury is initially caused by reduced blood supply to the tissues, which is …

Inflammatory responses are key players in myocardial ischemia/reperfusion (I/R) injury. Our
previous studies showed that resveratrol alleviated I/R injury in myocardial I/R animal …

Reperfusion of patients after myocardial infarction (heart attack) triggers cardiac
inflammation that leads to infarct expansion and heart failure (HF). We previously showed …

Among numerous cardiovascular diseases, heart failure is a final and fatal stage, and its
morbidity, mortality, and rehospitalization rate remain high, which reduces the exercise …

The NLR family pyrin domain containing 3 (NLRP3) inflammasome matures interleukin (IL)-
1β and induces inflammation. The molecular chaperone heat shock protein 90 (Hsp90) is …