There is growing interest regarding the use of minimally invasive “liquid biopsies” to identify
new biomarkers. Urinary extracellular vesicles (UEv) are nanovesicles released into urine …

Idiopathic nephrotic syndrome (INS) is the most frequent primary glomerular disease in
children, displaying high grade proteinuria and oedema. The mainstay of therapy are …

Most biological fluids contain extracellular vesicles (EVs). EVs are surrounded by a lipid
bilayer and contain biological macromolecules such as proteins, lipids, RNA, and DNA …

Congenital disorders characterized by the quantitative and qualitative reduction in the
number of functional nephrons are the primary cause of chronic kidney disease (CKD) in …

The primary function of the kidneys is to maintain systemic homeostasis (disruption of renal
structure and function results in multilevel impairment of body function). Kidney diseases are …

Urinary extracellular vesicles (EVs) are an attractive resource for biomarker discovery. In this
thesis we hypothesize that unique urine EV protein signatures are useful in two contexts:(i) …

The area of kidney diseases is a wide and complex field, and many conditions leading to
them are not fully understood or curable. Along with a better understanding of these …

Abstract Idiopathic Nephrotic Syndrome (INS) is a common childhood glomerular disease
requiring intense immunosuppressive drug treatments. Prediction of treatment response and …

Extracellular vesicles (EVs) are fascinating nano-sized subjects extensively studied over the
recent years across several disparate disciplines. EVs are endlessly secreted into the …

Extracellular vesicles have been isolated in various body fluids, including urine. The cargo
of urinary extracellular vesicles (uEVs) is composed of proteins and nucleic acids reflecting …