Chronic stress which is common in the current society can be harmful to female reproduction
and is associated with oocyte defects. However, the underlying mechanisms remain largely …

The quality of postovulatory metaphase II oocytes undergoes a time-dependent deterioration
as a result of the aging process. Melatonin is considered to be an anti-aging agent …

Age-related decline in female fertility is a common feature that occurs in the fourth decade of
women as a result of a reduction in both oocyte quality and quantity [1]. However, strategies …

It has been widely reported that advanced maternal age impairs oocyte quality. To date,
various molecules have been discovered to be involved in this process. However …

Increasing evidence shows that melatonin protected against age-related mitochondrial
oxidative damage. However, the protective effects of melatonin against ovarian aging has …

With increase in women's age, the reproductive capability of female mammals decreases
dramatically caused by age-related oxidative stress, coinciding with the decline in the …

Maternal obesity in humans is associated with poor outcomes across the reproductive
spectrum. Emerging evidence indicates that these defects are likely attributed to factors …

Mammalian oocytes remain arrested at the first prophase of meiosis in ovarian follicles for
an extended period. During this protracted arrest, oocytes are remarkably susceptible to the …

Abstract STUDY QUESTION Is SIRT1 involved in the oxidative stress (OS) response in
mouse oocytes? SUMMARY ANSWER SIRT1 plays a pivotal role in the adaptive response …

In mammalian ovaries, oocytes are physically coupled to somatic granulosa cells, and this
coupling is crucial for the growth and development of competent oocytes as it mediates the …