SIRT2, a member of the sirtuin family, has been recently shown to exert important effects on
mitosis and/or metabolism. However, its roles in oocyte maturation have not been fully …

Mitochondria in oocytes play important roles in many processes, including early embryo
development. Promotion of mitochondrial degradation and biogenesis through Sirtuin 1 …

Busulfan is a widely used chemotherapeutic drug for chronic myelogenous leukemia and
bone marrow transplantation. As a cell cycle nonspecific alkylation agent, busulfan has a …

After ovulation, metaphase II oocytes undergo a time-dependent deterioration in vivo or in
vitro, which is referred to as postovulatory oocyte aging, a process during which a series of …

Overweight or obese women seeking pregnancy is becoming increasingly common. Human
maternal obesity gives rise to detrimental effects during reproduction. Emerging evidence …

Abstract Mammalian Target of Rapamycin (mTOR) signaling pathway has important roles in
the regulation of puberty onset, gonadotropin secretion, follicular development and …

A thorough understanding of epigenetics regulatory mechanisms of premature ovarian
failure (POF) is still lacking. Here, we found that cyclophosphamide induced significantly …

Melatonin, the major pineal secretory product, has a significant impact on the female
reproductive system. Recently, the beneficial effects of melatonin on mammalian oocyte …

Deoxynivalenol (DON) is one of the most prevalent fusarium mycotoxins in feedstuff and
food. DON causes detrimental effects on human and animal reproductive systems by …

Levels of cotinine, a major metabolite of nicotine, have been positively correlated with risks
of cigarette smoking-related diseases. Melatonin is synthesized by the pineal gland and has …