The present study aimed to investigate the effect of melatonin (MT) supplementation on in
vitro maturation of vitrified mouse germinal vesicle (GV) oocytes. The fresh oocytes were …

Mammalian gametes and embryos are particularly vulnerable to oxidative stress-induced
damage, which is mainly caused by reactive oxygen species (ROS) originating from normal …

Previous studies suggest that the inclusion of melatonin (MTn) in in vitro maturation
protocols improves the developmental competence of oocytes by scavenging reactive …

Abstract Sirtuin-3 (SIRT3), the main deacetylase in the mitochondria, maintains cellular
energy metabolism and redox balance by deacetylating mitochondrial proteins in a NAD+ …

Endometriosis an important cause of female infertility and seriously impact physical and
psychological health of patients. Endometriosis is now considered to be a public health …

The quality of oocytes determines their development competence, which will be rapidly lost if
the oocytes are not fertilized at the proper time after ovulation. SIRT1, one of the sirtuin …

Oocyte in vitro maturation is crucial for in vitro embryo production technology, which
provides oocytes resources for in vitro fertilization and somatic cell nuclear transfer. Previous …

Embryo development potential and reproductive clinical outcomes are all deeply rooted in
oocyte maturation. Melatonin has been reported to promote oocyte maturation as an …

Under endoplasmic reticulum (ER)‐stress conditions, the unfolded protein response (UPR)
generates a defense mechanism in mammalian cells. The regulation of UPR signaling is …

Women with diminished ovarian reserve (DOR) have reduced fertility, but the underlying
regulation of ovarian function remains unknown. Although differential microRNA (miRNA) …