Sepsis is an extensive life‐threatening illness that occurs due to an abnormal host response
that extends through the initial storm of inflammation and oxidative stress and terminates at …

Background: Sepsis is a life-threatening condition responsible for up to 20% of all global
deaths. Kidneys are among the most common organs implicated, yet the pathogenesis of …

OBJECTIVE: Sepsis-associated liver injury is responsible for the high morbidity and mortality
rates seen with septic shock. Activation of the renin-angiotensin-aldosterone system (RAAS) …

The renin-angiotensin-aldosterone system (RAAS) plays a major role in the regulation of
blood pressure, renal hemodynamic, myocardial contractility via an enzymatic cascade …

Importance of the field: Severe sepsis is characterized by relative hypotension associated
with a high cardiac output, peripheral vasodilation, and organ dysfunction. The renin …

Sepsis and sepsis-related acute lung injuries (ALIs) are one of the main causes of death
among hospitalized patients. Renin–angiotensin–aldosterone system (RAAS) has been …

Kidney ischemia/reperfusion (I/R) injury is a leading cause of acute kidney injury (AKI)
occurring frequently under major surgeries and sepsis. This study aimed to evaluate the …

SA-AKI is a common condition that can involve disturbances in the RAS, particularly the
canonical angiotensin-converting enzyme (ACE) angiotensin-II (Ang II)/angiotensin II …

Sepsis is the main cause of death following infection and is regarded as a worldwide health
problem. Sepsis is a systemic inflammatory side consequence of microbial infection. To …

BACKGROUND: The incidence and mortality of septic acute kidney injury (AKI) remains
high, whereas our understanding of pathogenesis for septic AKI is still limited …