[HTML][HTML] The enigmatic role of viruses in multiple sclerosis: molecular mimicry or disturbed immune surveillance?

J Geginat, M Paroni, M Pagani, D Galimberti… - Trends in …, 2017 - cell.com
Multiple sclerosis (MS) is a T cell driven autoimmune disease of the central nervous system
(CNS). Despite its association with Epstein-Barr Virus (EBV), how viral infections promote …

Epstein-Barr virus-specific CD8 T cells selectively infiltrate the brain in multiple sclerosis and interact locally with virus-infected cells: clue for a virus-driven …

B Serafini, B Rosicarelli, C Veroni, GA Mazzola… - Journal of …, 2019 - Am Soc Microbiol
Epstein-Barr virus (EBV) is a ubiquitous herpesvirus strongly associated with multiple
sclerosis (MS), a chronic inflammatory disease of the central nervous system (CNS) …

Multiple sclerosis–a response-to-damage model

BA't Hart, RQ Hintzen, JD Laman - Trends in molecular medicine, 2009 - cell.com
According to a widely supported but unproven concept, the autoimmune mechanisms that
drive neuroinflammation in multiple sclerosis (MS) are triggered by virus infection. However …

[PDF][PDF] Ineffective control of Epstein-Barr-virus-induced autoimmunity increases the risk for multiple sclerosis

H Vietzen, SM Berger, LM Kühner, PL Furlano, G Bsteh… - Cell, 2023 - cell.com
Multiple sclerosis (MS) is a demyelinating disease of the CNS. Epstein-Barr virus (EBV)
contributes to the MS pathogenesis because high levels of EBV EBNA 386–405-specific …

[HTML][HTML] Viral triggers of multiple sclerosis

K Kakalacheva, C Münz, JD Lünemann - Biochimica et Biophysica Acta …, 2011 - Elsevier
Genetic and environmental factors jointly determine the susceptibility to develop Multiple
Sclerosis (MS). Collaborative efforts during the past years achieved substantial progress in …

[HTML][HTML] Altered immune response to the epstein–barr virus as a prerequisite for multiple sclerosis

F Läderach, C Münz - Cells, 2022 - mdpi.com
Strong epidemiologic evidence links Epstein–Barr virus (EBV) infection and its altered
immune control to multiple sclerosis (MS) development. Clinical MS onset occurs years after …

[HTML][HTML] Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs

Q Ji, A Perchellet, JM Goverman - Nature immunology, 2010 - nature.com
Multiple sclerosis is an inflammatory, demyelinating, central nervous system disease
mediated by myelin-specific T cells. Environmental triggers that cause the breakdown of …

Viral-induced suppression of self-reactive T cells: lessons from neurotropic coronavirus-induced demyelination

C Savarin, CC Bergmann - Journal of neuroimmunology, 2017 - Elsevier
Genetic and environmental factors, ie infections, have been proposed to contribute to
disease induction and relapsing events in multiple sclerosis (MS), an autoimmune …

Viruses can silently prime for and trigger central nervous system autoimmune disease

DJ Theil, I Tsunoda, F Rodriguez, JL Whitton… - Journal of …, 2001 - Springer
Although many viruses have been isolated from patients with multiple sclerosis (MS), as yet,
no one agent has been demonstrated to cause MS. In contrast, epidemiological data …

Defective T‐cell control of Epstein–Barr virus infection in multiple sclerosis

MP Pender, PA Csurhes, JM Burrows… - Clinical & …, 2017 - Wiley Online Library
Mounting evidence indicates that infection with Epstein–Barr virus (EBV) has a major role in
the pathogenesis of multiple sclerosis (MS). Defective elimination of EBV‐infected B cells by …