Epitope spreading and molecular mimicry as triggers of autoimmunity in the Theiler's virus-induced demyelinating disease model of multiple sclerosis

JL Croxford, JK Olson, SD Miller - Autoimmunity reviews, 2002 - Elsevier
The pathogenesis of multiple sclerosis (MS), a human demyelinating disease of the central
nervous system (CNS), is currently unknown. It is widely thought that MS is an autoimmune …

Protective and detrimental roles for regulatory T cells in a viral model for multiple sclerosis

NE Martinez, F Karlsson, F Sato, E Kawai… - Brain …, 2014 - Wiley Online Library
Multiple sclerosis (MS) has been proposed to be an immune‐mediated disease in the
central nervous system (CNS) that can be triggered by virus infections. In T heiler's murine …

EBV infection and multiple sclerosis: lessons from a marmoset model

A Bert, YS Kap, E Morandi, JD Laman… - Trends in molecular …, 2016 - cell.com
Multiple sclerosis (MS) is thought to be initiated by the interaction of genetic and
environmental factors, eliciting an autoimmune attack on the central nervous system. Epstein …

Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis

M Kaufmann, H Evans, AL Schaupp, JB Engler, G Kaur… - Med, 2021 - cell.com
Background Multiple sclerosis (MS), an autoimmune disease of the central nervous system
(CNS), can be suppressed in its early stages but eventually becomes clinically progressive …

B and T cells driving multiple sclerosis: identity, mechanisms and potential triggers

J Van Langelaar, L Rijvers, J Smolders… - Frontiers in …, 2020 - frontiersin.org
Historically, multiple sclerosis (MS) has been viewed as being primarily driven by T cells.
However, the effective use of anti-CD20 treatment now also reveals an important role for B …

Cumulative roles for Epstein-Barr virus, human endogenous retroviruses, and human herpes virus-6 in driving an inflammatory cascade underlying MS pathogenesis

UC Meier, RC Cipian, A Karimi, R Ramasamy… - Frontiers in …, 2021 - frontiersin.org
Roles for viral infections and aberrant immune responses in driving localized
neuroinflammation and neurodegeneration in multiple sclerosis (MS) are the focus of …

High‐throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV‐reactive CD8+ T cells

A Lossius, JN Johansen, F Vartdal… - European journal of …, 2014 - Wiley Online Library
Epstein‐Barr virus (EBV) has long been suggested as a pathogen in multiple sclerosis (MS).
Here, we used high‐throughput sequencing to determine the diversity …

Differential expression of inflammatory cytokines parallels progression of central nervous system pathology in two clinically distinct models of multiple sclerosis

WS Begolka, CL Vanderlugt, SM Rahbe… - The Journal of …, 1998 - journals.aai.org
Multiple sclerosis is an immune-mediated demyelinating disease of unknown etiology that
presents with either a chronic-progressive or relapsing-remitting clinical course. Theiler's …

Role of viruses in the pathogenesis of multiple sclerosis

RE Tarlinton, E Martynova, AA Rizvanov… - Viruses, 2020 - mdpi.com
Multiple sclerosis (MS) is an immune inflammatory disease, where the underlying etiological
cause remains elusive. Multiple triggering factors have been suggested, including …

Infections, vaccines and autoimmunity: a multiple sclerosis perspective

D Jakimovski, B Weinstock-Guttman, M Ramanathan… - Vaccines, 2020 - mdpi.com
Background: Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative
disease that is associated with multiple environmental factors. Among suspected …