Epitope spreading and molecular mimicry as triggers of autoimmunity in the Theiler's virus-induced demyelinating disease model of multiple sclerosis
The pathogenesis of multiple sclerosis (MS), a human demyelinating disease of the central
nervous system (CNS), is currently unknown. It is widely thought that MS is an autoimmune …
nervous system (CNS), is currently unknown. It is widely thought that MS is an autoimmune …
Protective and detrimental roles for regulatory T cells in a viral model for multiple sclerosis
NE Martinez, F Karlsson, F Sato, E Kawai… - Brain …, 2014 - Wiley Online Library
Multiple sclerosis (MS) has been proposed to be an immune‐mediated disease in the
central nervous system (CNS) that can be triggered by virus infections. In T heiler's murine …
central nervous system (CNS) that can be triggered by virus infections. In T heiler's murine …
EBV infection and multiple sclerosis: lessons from a marmoset model
Multiple sclerosis (MS) is thought to be initiated by the interaction of genetic and
environmental factors, eliciting an autoimmune attack on the central nervous system. Epstein …
environmental factors, eliciting an autoimmune attack on the central nervous system. Epstein …
Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis
Background Multiple sclerosis (MS), an autoimmune disease of the central nervous system
(CNS), can be suppressed in its early stages but eventually becomes clinically progressive …
(CNS), can be suppressed in its early stages but eventually becomes clinically progressive …
B and T cells driving multiple sclerosis: identity, mechanisms and potential triggers
J Van Langelaar, L Rijvers, J Smolders… - Frontiers in …, 2020 - frontiersin.org
Historically, multiple sclerosis (MS) has been viewed as being primarily driven by T cells.
However, the effective use of anti-CD20 treatment now also reveals an important role for B …
However, the effective use of anti-CD20 treatment now also reveals an important role for B …
Cumulative roles for Epstein-Barr virus, human endogenous retroviruses, and human herpes virus-6 in driving an inflammatory cascade underlying MS pathogenesis
Roles for viral infections and aberrant immune responses in driving localized
neuroinflammation and neurodegeneration in multiple sclerosis (MS) are the focus of …
neuroinflammation and neurodegeneration in multiple sclerosis (MS) are the focus of …
High‐throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV‐reactive CD8+ T cells
A Lossius, JN Johansen, F Vartdal… - European journal of …, 2014 - Wiley Online Library
Epstein‐Barr virus (EBV) has long been suggested as a pathogen in multiple sclerosis (MS).
Here, we used high‐throughput sequencing to determine the diversity …
Here, we used high‐throughput sequencing to determine the diversity …
Differential expression of inflammatory cytokines parallels progression of central nervous system pathology in two clinically distinct models of multiple sclerosis
WS Begolka, CL Vanderlugt, SM Rahbe… - The Journal of …, 1998 - journals.aai.org
Multiple sclerosis is an immune-mediated demyelinating disease of unknown etiology that
presents with either a chronic-progressive or relapsing-remitting clinical course. Theiler's …
presents with either a chronic-progressive or relapsing-remitting clinical course. Theiler's …
Role of viruses in the pathogenesis of multiple sclerosis
RE Tarlinton, E Martynova, AA Rizvanov… - Viruses, 2020 - mdpi.com
Multiple sclerosis (MS) is an immune inflammatory disease, where the underlying etiological
cause remains elusive. Multiple triggering factors have been suggested, including …
cause remains elusive. Multiple triggering factors have been suggested, including …
Infections, vaccines and autoimmunity: a multiple sclerosis perspective
Background: Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative
disease that is associated with multiple environmental factors. Among suspected …
disease that is associated with multiple environmental factors. Among suspected …