[HTML][HTML] Comprehensive investigations relationship between viral infections and multiple sclerosis pathogenesis

S Sedighi, O Gholizadeh, S Yasamineh… - Current …, 2023 - Springer
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous
system (CNS). Compared to other types of self-limiting myelin disorders, MS …

[HTML][HTML] Epstein Barr virus exploits genetic susceptibility to increase multiple sclerosis risk

F Läderach, C Münz - Microorganisms, 2021 - mdpi.com
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) for
which both genetic and environmental risk factors have been identified. The strongest …

[HTML][HTML] Innate immune responses and viral-induced neurologic disease

Y Cheng, DD Skinner, TE Lane - Journal of clinical medicine, 2018 - mdpi.com
Multiple sclerosis (MS) is a disease of the central nervous system (CNS) characterized by
chronic neuroinflammation, axonal damage, and demyelination. Cellular components of the …

[HTML][HTML] Immune and Epstein-Barr virus gene expression in cerebrospinal fluid and peripheral blood mononuclear cells from patients with relapsing-remitting multiple …

C Veroni, F Marnetto, L Granieri, A Bertolotto… - Journal of …, 2015 - Springer
Background Gene expression analyses in paired cerebrospinal fluid (CSF) and peripheral
blood mononuclear cells (PBMC) from patients with multiple sclerosis (MS) are restrained by …

The essential role of Epstein-Barr virus in the pathogenesis of multiple sclerosis

MP Pender - The Neuroscientist, 2011 - journals.sagepub.com
There is increasing evidence that infection with the Epstein-Barr virus (EBV) plays a role in
the development of multiple sclerosis (MS), a chronic inflammatory demyelinating disease of …

[HTML][HTML] Pro-inflammatory functions of astrocytes correlate with viral clearance and strain-dependent protection from TMEV-induced demyelinating disease

PA Carpentier, MT Getts, SD Miller - Virology, 2008 - Elsevier
Intracerebral infection of susceptible strains of mice, eg SJL/J, with Theiler's murine
encephalomyelitis virus (TMEV) leads to a persistent CNS infection accompanied by …

Autoantibody-boosted T-cell reactivation in the target organ triggers manifestation of autoimmune CNS disease

AC Flach, T Litke, J Strauss, M Haberl… - Proceedings of the …, 2016 - National Acad Sciences
Multiple sclerosis (MS) is caused by T cells that are reactive for brain antigens. In
experimental autoimmune encephalomyelitis, the animal model for MS, myelin-reactive T …

Multiple sclerosis: immune mechanism and update on current therapies

S Bansil, SD Cook… - Annals of Neurology …, 1995 - Wiley Online Library
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS)
afflicting approximately 250,000 individuals in the United States. This inflammatory disease …

Recognition of viral and self-antigens by TH1 and TH1/TH17 central memory cells in patients with multiple sclerosis reveals distinct roles in immune surveillance and …

M Paroni, V Maltese, M De Simone, V Ranzani… - Journal of Allergy and …, 2017 - Elsevier
Background Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central
nervous system (CNS) that is caused by autoreactive T cells and associated with viral …

[HTML][HTML] Endogenous retroviruses and multiple sclerosis–new pieces to the puzzle

KK Nissen, MJ Laska, B Hansen, T Terkelsen… - BMC neurology, 2013 - Springer
The possibility that retroviruses play a role in multiple sclerosis (MS) has long been
considered; accumulating findings suggest this to be most likely in the form of human …