[HTML][HTML] Multiple sclerosis: mechanisms and immunotherapy

C Baecher-Allan, BJ Kaskow, HL Weiner - Neuron, 2018 - cell.com
Multiple sclerosis (MS) is an autoimmune disease triggered by environmental factors that act
on a genetically susceptible host. It features three clinical stages: a pre-clinical stage …

Epstein-Barr virus as a driver of multiple sclerosis

LM Sollid - Science Immunology, 2022 - science.org
Accumulating evidence implicates Epstein-Barr virus (EBV) as an etiological factor in
multiple sclerosis (MS). If EBV is a “driver” that causes antiviral immunity with associated …

Recognition of viral and self-antigens by TH1 and TH1/TH17 central memory cells in patients with multiple sclerosis reveals distinct roles in immune surveillance and …

M Paroni, V Maltese, M De Simone, V Ranzani… - Journal of Allergy and …, 2017 - Elsevier
Background Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central
nervous system (CNS) that is caused by autoreactive T cells and associated with viral …

The immune response in multiple sclerosis

S Rodríguez Murúa, MF Farez… - Annual Review of …, 2022 - annualreviews.org
Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative
disease that affects the central nervous system (CNS). MS is characterized by immune …

Role of viruses in etiology and pathogenesis of multiple sclerosis

SS Soldan, S Jacobson - Advances in virus research, 2001 - Elsevier
Publisher Summary Multiple sclerosis (MS) is the most prevalent demyelinating disease of
young adults, affecting an estimated 300,000 individuals in the United States alone. The …

Latent virus infection upregulates CD40 expression facilitating enhanced autoimmunity in a model of multiple sclerosis

C Casiraghi, A Citlali Márquez, I Shanina… - Scientific reports, 2015 - nature.com
Epstein-Barr virus (EBV) has been identified as a putative environmental trigger of multiple
sclerosis (MS) by multiple groups working worldwide. Previously, we reported that when …

Epstein–Barr virus as a leading cause of multiple sclerosis: mechanisms and implications

K Bjornevik, C Münz, JI Cohen, A Ascherio - Nature Reviews Neurology, 2023 - nature.com
Epidemiological studies have provided compelling evidence that multiple sclerosis (MS) is a
rare complication of infection with the Epstein–Barr virus (EBV), a herpesvirus that infects …

Multiple sclerosis immunology: the healthy immune system vs the MS immune system

LH Kasper, J Shoemaker - Neurology, 2010 - AAN Enterprises
Multiple sclerosis (MS) is a debilitating autoimmune disease characterized by both
inflammation and axonal degeneration. The resulting demyelination and subsequent …

Virus-mediated autoimmunity in multiple sclerosis

N Grigoriadis, GM Hadjigeorgiou - Journal of autoimmune diseases, 2006 - Springer
Epidemiological data suggest the notion that in Multiple Sclerosis (MS) is an acquired
autoimmune disease and the cause may be an environmental factor (s), probably infectious …

Multiple sclerosis: are protective immune mechanisms compromised by a complex infectious background?

B Krone, JM Grange - Autoimmune diseases, 2011 - Wiley Online Library
The immunological background of multiple sclerosis (MS) manifests as an altered reactivity
against a diverse range of infections, particularly with the Epstein‐Barr virus. Although this …