Revisiting the pathoetiology of multiple sclerosis: has the tail been wagging the mouse?

MK Sen, MSM Almuslehi, PJ Shortland… - Frontiers in …, 2020 - frontiersin.org
Multiple Sclerosis (MS) is traditionally considered an autoimmune-mediated demyelinating
disease, the pathoetiology of which is unknown. However, the key question remains whether …

[HTML][HTML] Axonal pathology and demyelination in viral models of multiple sclerosis

JE Libbey, TE Lane, RS Fujinami - Discovery medicine, 2014 - ncbi.nlm.nih.gov
Multiple sclerosis (MS) is an immune-mediated inflammatory demyelinating disease of the
central nervous system (CNS). Monozygotic twin studies suggest that while there is a …

Recognition of conserved amino acid motifs of common viruses and its role in autoimmunity

M Sospedra, Y Zhao, H Hausen, PA Muraro… - PLoS …, 2005 - journals.plos.org
The triggers of autoimmune diseases such as multiple sclerosis (MS) remain elusive.
Epidemiological studies suggest that common pathogens can exacerbate and also induce …

Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis

R Martin, M Sospedra, M Rosito… - European journal of …, 2016 - Wiley Online Library
Multiple sclerosis (MS) is the most common inflammatory disorder of the central nervous
system (CNS) in young adults. When MS is not treated, it leads to irreversible and severe …

Persisting viruses and autoimmunity

M Paroli, E Schiaffella, F Di Rosa, V Barnaba - Journal of …, 2000 - Elsevier
Viral infections can be responsible for the onset and sustaining of autoimmune processes.
We discuss how chronic inflammation associated with viral persistence is the prerequisite for …

Involvement of cytotoxic Eomes-expressing CD4+ T cells in secondary progressive multiple sclerosis

BJE Raveney, W Sato, D Takewaki… - Proceedings of the …, 2021 - National Acad Sciences
Multiple sclerosis (MS), a putative autoimmune disease of the central nervous system (CNS),
commonly presents as relapsing-remitting MS (RRMS), characterized by recurrent episodes …

Role of peripheral immune cells in multiple sclerosis and experimental autoimmune encephalomyelitis

S Dhaiban, M Al-Ani, NM Elemam, MH Al-Aawad… - Sci, 2021 - mdpi.com
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the myelination of the
neurons present in the central nervous system (CNS). The exact etiology of MS development …

Activation of myelin reactive T cells in multiple sclerosis: a possible role for T cell degeneracy?

P Stinissen, N Hellings - European journal of immunology, 2008 - Wiley Online Library
While it is widely accepted that myelin reactive T cells are key players in the
immunopathogenesis of multiple sclerosis (MS), the initial triggers that turn on these self …

Exposure to the Epstein–Barr Viral Antigen Latent Membrane Protein 1 Induces Myelin-Reactive Antibodies In Vivo

Y Lomakin, GP Arapidi, A Chernov… - Frontiers in …, 2017 - frontiersin.org
Multiple sclerosis (MS) is an autoimmune chronic inflammatory disease of the central
nervous system (CNS). Cross-reactivity of neuronal proteins with exogenous antigens is …

Multiple sclerosis-a coordinated immune attack across the blood brain barrier

B Hemmer, S Cepok, D Zhou… - Current neurovascular …, 2004 - ingentaconnect.com
Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS). The
acquired immune system plays a central role in the pathogenesis of MS although target …