Cell cooperation promotes many of the hallmarks of cancer via the secretion of diffusible
factors that can affect cancer cells or stromal cells in the tumour microenvironment. This …

The evolution of cooperation has a well established theoretical framework based on game
theory. This approach has made valuable contributions to a wide variety of disciplines …

The accumulation of somatic mutations, to which the cellular genome is permanently
exposed, often leads to cancer. Analysis of any tumour shows that, besides the malignant …

The population of cells that comprises a tumour may consist of genetically different
individuals. Often, such polymorphisms result from the expansion of a new, advantageous …

Importance While systemic therapy for disseminated cancer is often initially successful,
malignant cells, using diverse adaptive strategies encoded in the human genome, almost …

Evolutionary game theory mathematically conceptualizes and analyzes biological
interactions where one's fitness not only depends on one's own traits, but also on the traits of …

Heterogeneity in strategies for survival and proliferation among the cells that constitute a
tumour is a driving force behind the evolution of resistance to cancer therapy. The rules …

Quantitative models from population biology and evolutionary game theory frame the tumor-
host interface as a dynamical microenvironment of competing tumor and normal …

Chemotherapy for metastatic cancer commonly fails due to evolution of drug resistance in
tumor cells. Here, we view cancer treatment as a game in which the oncologists choose a …

Tumors are complex cellular and acellular environments within which cancer clones are
under continuous selection pressures. Cancer cells are in a permanent mode of interaction …