RNA splicing is an important driver of heterogeneity in single cells, both through the
expression of alternative transcripts and as a major determinant of transcriptional kinetics …

RNA splicing is an important driver of heterogeneity in single cells through the expression of
alternative transcripts and as a determinant of transcriptional kinetics. However, the intrinsic …

Single-cell RNA-seq is widely used for transcriptome profiling, but most analyses have
focused on gene-level events, with much less attention devoted to alternative splicing. Here …

The emergence of single-cell RNA-seq (scRNA-seq) technology has made it possible to
measure gene expression variations at cellular level. This breakthrough enables the …

Motivation: Short-read single-cell RNA-sequencing (scRNA-seq) has been used to study
cellular heterogeneity, cellular fate, and transcriptional dynamics. Modeling splicing …

Alternative splicing (AS) contributes significantly to RNA and protein variability yet its role in
defining cellular diversity is not fully understood. While Smart-seq2 offers enhanced …

Alternative splicing shapes the transcriptome and contributes to each cell's unique identity,
but single-cell RNA sequencing (scRNA-seq) has struggled to capture the impact of …

Motivation The RNA splicing efficiency is of high interest for both understanding the
regulatory machinery of gene expression and estimating the RNA velocity in single cells …

Alternative splicing is an important source of heterogeneity underlying gene expression
between individual cells but remains an understudied area due to the paucity of …

Single-cell RNA-seq (scRNA-seq) provides a comprehensive measurement of stochasticity
in transcription, but the limitations of the technology have prevented its application to dissect …