Single-cell RNA-sequencing (scRNA-seq) provides unprecedented insights into cellular
heterogeneity. Although scRNA-seq reads from most prevalent and popular tagged-end …

A vast amount of public RNA-sequencing datasets have been generated and used widely to
study transcriptome mechanisms. These data offer precious opportunity for advancing …

Alternative splicing is a core biological process that enables profound and essential
diversification of gene function. Short-read RNA sequencing approaches fail to resolve RNA …

RNA-seq analysis of alternative pre-mRNA splicing has facilitated an unprecedented
understanding of transcriptome complexity in health and disease. However, despite the …

Differences in alternative splicing patterns can reveal important markers of phenotypic
differentiation, including biomarkers of disease. Emerging large and complex RNA-seq …

The RNA transcriptome varies in response to cellular differentiation as well as
environmental factors, and can be characterized by the diversity and abundance of transcript …

Background Introns are generally removed from primary transcripts to form mature RNA
molecules in a post-transcriptional process called splicing. An efficient splicing of primary …

Background Through alternative splicing, most human genes produce multiple isoforms in a
cell-, tissue-, and disease-specific manner. Numerous studies show that alternative splicing …

Background Alternative splicing is a key regulatory mechanism in eukaryotic cells and
increases the effective number of functionally distinct gene products. Using bulk RNA …

Analysis of alternative splicing in single-cell RNA sequencing (scRNA-seq) is challenging
due to its inherent technical noise and generally low sequencing depth. We present SCATS …