Tyrosinase (TYR) is a key enzyme for melanin production. We previously showed that
hinokitiol, a naturally occurring seven-membered ring terpenoid, potently inhibits human …

BACKGROUND: Melanogenesis is regulated by a series of enzymes under the control of
microphthalmia-associated transcription factor (MITF). OBJECTIVE: The aim of this study …

H inokitiol purified from the heartwood of cupressaceous plants has had various biological
functions of cell differentiation and growth. Hinokitiol has been demonstrated as having an …

In this study, the effects of (−)-epigallocatechin-3-gallate (EGCG) and/or hinokitiol (β-
thujaplicin) on melanogenesis were investigated. Our results showed that both EGCG and …

Lyoniresinol was one of the eight lignans purified from methanol extract of Vitex negundo
and was shown to have robust tyrosinase inhibitory capacity. However, the mechanism of its …

Tyrosinase and its transcriptional regulator microphthalmia-associated transcription factor
(MITF) play critical roles in regulation of melanogenesis, and are required for environmental …

Abstract N, N, N-trimethyl phytosphingosine-iodide (TMP) was recently developed as an
antitumor agent. We examined the effects of TMP on melanogenesis and its related …

Previously, we reported that a fungal metabolite, terrein, decreases melanin synthesis via
downregulation of microphthalmia‐associated transcription factor (MITF). In the present …

Objectives We have investigated whether KHG25855 (2-cyclohexylamino-1, 3-thiazole
hydrochloride) affected melanogenesis in B16 mouse melanoma cells, and the mechanisms …

Recently, it has been found that Asiasari radix showed a hypopigmenting effect on
melanogenesis through activation of mitogen-activated protein kinase (MEK)/extracellular …