Activation of the type 1 interferon response is extensively connected to the pathogenesis of
autoimmune diseases. Loss of function of Immunity Related GTPase M (IRGM) has also …

ABSTRACT IRGM is a genetic risk factor for several autoimmune diseases. However, the
mechanism of IRGM-mediated protection in autoimmunity remains undetermined. The …

IFN-γ is a pleiotropic cytokine that plays a key role in host resistance, yet when not properly
regulated can become detrimental to the host. The interferon-inducible Immunity Related …

The immunity-related GTPases (IRGs) are a family of proteins that are induced by interferon
(IFN)-γ and play pivotal roles in immune and inflammatory responses. IRGs ostensibly …

Abstract Immunity Related GTPases (IRG) are a family of proteins produced during infection
that regulate membrane remodeling events in cells, particularly autophagy and mitophagy …

Mitochondrial abnormalities have been noted in lupus, but the causes and consequences
remain obscure. Autophagy-related genes ATG5, ATG7 and IRGM have been previously …

Glucocorticoids remain a mainstay of modern medicine due to their ability to broadly
suppress immune activation. However, they cause severe adverse effects that warrant …

IRGM, a human immunity-related GTPase, confers autophagic defence against intracellular
pathogens by an unknown mechanism. Here, we report an unexpected mode of IRGM …

Background The interferon-γ (IFN-γ)-inducible immunity-related GTPase (IRG), Irgm1, plays
an essential role in restraining activation of the IRG pathogen resistance system. However …

Interferon-γ (IFN-γ) and tumor necrosis factor (TNF) are essential cytokines for successful
clearance of microbial infections. Activation of macrophages by synergistic effects of these …