Genome stability is an integral feature of all living organisms. Aneuploidy is the most
common cause of fetal death in humans. The timing of bursts in increased aneuploidy …

In mouse and most other mammalian species, the paternal and maternal genomes undergo
parent-specific epigenetic reprogramming during preimplantation development. The …

The fertilized mouse egg actively demethylates the paternal genome within a few hours after
fertilization, whereas the maternal genome is only passively demethylated by a replication …

DNA methylation is involved in a number of important processes such as maintaining
genome stability, silencing of retrotransposons, co-ordinating mono-alleleic expression of …

DNA methylation is an epigenetic mark that is erased in the early embryo and then re-
established at the time of implantation. In this Review, dynamics of DNA methylation during …

DNA methylation is dynamically remodelled during the mammalian life cycle through distinct
phases of reprogramming and de novo methylation. These events enable the acquisition of …

In the normal diploid mouse embryo, active demethylation of the paternal genome but not of
the maternal genome occurs within only a few hours and in a highly coordinated fashion as …

Abstract Development from separate parental germ cells through fertilization and
proceeding to a fully functioning adult animal occurs through an intricate program of …

DNA methylation occurs on cytosines, is catalyzed by DNA methyltransferases (DNMTs),
and is present at high levels in all vertebrates. DNA methylation plays essential roles in …

Drastic epigenetic reprogramming occurs during human gametogenesis and early embryo
development. Advances in low-input and single-cell epigenetic techniques have provided …