Aims/hypothesis Nutrient overabundance and diminished physical activity underlie the
epidemic of obesity and its consequences of insulin resistance and type 2 diabetes. These …

Objective SIRT1 has been proposed to be a key signaling node linking changes in energy
metabolism to transcriptional adaptations. Although SIRT1 overexpression is protective …

Background There is evidence that sirtuin 1 (SIRT1), a key regulator of nutrient metabolism,
increases β-cell secretory function. Excess circulating fat, as seen in obesity, has been …

The Sir2 (silent information regulator 2) family of NAD‐dependent deacetylases regulates
aging and longevity across a wide variety of organisms, including yeast, worms, and flies. In …

Objective Recent studies have revealed that SIRT1 gain‐of‐function could promote adipose
tissue browning for the adaptive thermogenesis under normal diet. This study investigated …

Insulin resistance is often characterized as the most critical factor contributing to the
development of type 2 diabetes mellitus (T2DM). Sustained high glucose is an important …

Abstract Aims/hypothesis Sirtuin 1 (SIRT1) has emerged as a key metabolic regulator of
glucose homeostasis and insulin secretion. Enhanced SIRT1 activity has been shown to be …

Increasing SIRT1 dosage/activity is effective to provide significant protection from high-fat
diet-induced metabolic complications, suggesting that SIRT1 activation likely promotes …

Objective Available treatment for obesity and type 2 diabetes mellitus (T2DM) is suboptimal.
Thus, identifying novel molecular target (s) exerting protective effects against these …

The rising incidence of diabetes, metabolic syndrome, and subsequent vascular diseases is
now a major public health problem in industrialized countries. New therapeutic strategies to …