Old polyanionic drug suramin suppresses detrimental cytotoxicity of the host defense peptide LL-37
M Quemé-Peña, M Ricci, T Juhász… - ACS Pharmacology & …, 2020 - ACS Publications
The host defense peptide LL-37 is the only human cathelicidin, characterized by pleiotropic
activity ranging from immunological to anti-neoplastic functions. However, its overexpression …
activity ranging from immunological to anti-neoplastic functions. However, its overexpression …
Emerging roles of the host defense peptide LL‐37 in human cancer and its potential therapeutic applications
Human cathelicidin LL‐37, a host defense peptide derived from leukocytes and epithelial
cells, plays a crucial role in innate and adaptive immunity. Not only does LL‐37 eliminate …
cells, plays a crucial role in innate and adaptive immunity. Not only does LL‐37 eliminate …
Epithelial-Immune Cell Crosstalk Determines the Activation of Immune Cells In Vitro by the Human Cathelicidin LL-37 at Low Physiological Concentrations
IV Bogdanov, MA Streltsova, EI Kovalenko… - Biomolecules, 2023 - mdpi.com
The only human cathelicidin, LL-37, is a host defense antimicrobial peptide with
antimicrobial activities against protozoans, fungi, Gram (+) and Gram (−) bacteria, and …
antimicrobial activities against protozoans, fungi, Gram (+) and Gram (−) bacteria, and …
[HTML][HTML] The human cathelicidin antimicrobial peptide LL-37 and mimics are potential anticancer drugs
K Kuroda, K Okumura, H Isogai, E Isogai - Frontiers in oncology, 2015 - frontiersin.org
Antimicrobial peptides (AMPs) play a critical role in innate host defense against microbial
pathogens in many organisms. The human cathelicidin, LL-37, has a net positive charge …
pathogens in many organisms. The human cathelicidin, LL-37, has a net positive charge …
[HTML][HTML] The potentials of short fragments of human anti-microbial peptide LL-37 as a novel therapeutic modality for diseases
K Chen, W Gong, J Huang, T Yoshimura… - Frontiers in Bioscience …, 2021 - imrpress.com
Human cathelicidin antimicrobial peptide LL-37 (LL-37) is an antimicrobial peptide derived
from its precursor protein hCAP18, which is an only cathelicidin in human. LL-37 not only …
from its precursor protein hCAP18, which is an only cathelicidin in human. LL-37 not only …
[HTML][HTML] Significance of LL-37 on immunomodulation and disease outcome
B Yang, D Good, T Mosaiab, W Liu, G Ni… - BioMed Research …, 2020 - hindawi.com
LL-37, also called cathelicidin, is an important part of the human immune system, which can
resist various pathogens. A plethora of experiments have demonstrated that it has the …
resist various pathogens. A plethora of experiments have demonstrated that it has the …
Renovation as innovation: Repurposing human antibacterial peptide LL-37 for cancer therapy
F Lu, Y Zhu, G Zhang, Z Liu - Frontiers in Pharmacology, 2022 - frontiersin.org
In many organisms, antimicrobial peptides (AMPs) display wide activities in innate host
defense against microbial pathogens. Mammalian AMPs include the cathelicidin and …
defense against microbial pathogens. Mammalian AMPs include the cathelicidin and …
The roles of cathelicidin LL-37 in immune defences and novel clinical applications
A Nijnik, REW Hancock - Current opinion in hematology, 2009 - journals.lww.com
The understanding of the biological properties and functions of LL-37 and other host
defence peptides advances our knowledge of innate immunity, the interactions of the host …
defence peptides advances our knowledge of innate immunity, the interactions of the host …
Tissue-specific regulation of innate immune responses by human cathelicidin LL-37
P Chieosilapatham, S Ikeda, H Ogawa… - Current …, 2018 - ingentaconnect.com
Cathelicidins form one of the major families of antimicrobial peptides and have been
identified in many vertebrates, including humans. LL-37, the only human member of the …
identified in many vertebrates, including humans. LL-37, the only human member of the …
Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer
Cathelicidins are a family of bacteriocidal polypeptides secreted by macrophages and
polymorphonuclear leukocytes (PMN). LL-37, the only human cathelicidin, has been …
polymorphonuclear leukocytes (PMN). LL-37, the only human cathelicidin, has been …