Amyloid-β (Aβ) accumulation is a hallmark of Alzheimer's disease, although Aβ alone may
be insufficient to cause impairments. Modifiable health factors, including sleep, may mitigate …

Sleep monitoring may provide markers for future Alzheimer's disease; however, the
relationship between sleep and cognitive function in preclinical and early symptomatic …

Recent studies in mouse models of Alzheimer's disease (AD) and in humans suggest that
sleep disruption and amyloid-beta (Aβ) accumulation are interrelated, and may, thus …

Background: It is suggested that not all individuals with elevated A will develop dementia or
cognitive impairment. Environment or lifestyle might modulate the association of amyloid …

Importance Evidence shows that sleep dysfunction and β-amyloid (Aβ) deposition work
synergistically to impair brain function in individuals with normal cognition, increasing the …

Recent findings indicate that poor sleep is a risk factor for brain Aβ deposition, and Aβ
deposition contributes to sleep disruption. Through the conduct of more mechanistic studies …

Factors other than age and genetics may increase the risk of developing Alzheimer disease
(AD). Accumulation of the amyloid-β (Aβ) peptide in the brain seems to initiate a cascade of …

As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …

Importance Disrupted sleep is common in aging and is associated with cognition. Age-
related changes to sleep are associated with multiple causes, including early Alzheimer …

Sleep problems relate to brain changes in aging and disease, but the mechanisms are
unknown. Studies suggest a relationship between β-amyloid (Aβ) accumulation and sleep …