Eukaryotic human pathogens present a serious threat to global health, causing hundreds of
millions of infections with high death rate each year. Fungi and protozoa are two major …

Species of the fungal genus Aspergillus are significant human and agricultural pathogens
that are often refractory to existing antifungal treatments. Protein farnesyltransferase (FTase) …

Cryptococcus neoformans is a fungal pathogen that causes life-threatening infections in
immunocompromised individuals, including AIDS patients and transplant recipients. Few …

Infections by fungal pathogens are difficult to treat due to a paucity of antifungals and
emerging resistances. Next-generation antifungals therefore are needed urgently. We have …

New chemotherapeutics are urgently needed to combat malaria. We previously reported on
a novel series of antimalarial, ethylenediamine-based inhibitors of protein …

Phenotypic screens are effective starting points to identify compounds with desirable
activities. To find novel antifungals, we conducted a phenotypic screen in Saccharomyces …

Farnesyltransferase inhibitors (FTIs) are focus for the treatment of several diseases,
particularly in the field of cancer therapy. Their potential, however, goes even further, as a …

Protein farnesyltransferase (FTase) catalyzes an essential posttranslational lipid
modification of more than 60 proteins involved in intracellular signal transduction networks …

New therapeutics to combat malaria are desperately needed. Here we show that the
enzyme protein farnesyltransferase (PFT) from the malaria parasite Plasmodium falciparum …

Third world nations require immediate access to inexpensive therapeutics to counter the
high mortality inflicted by malaria. Here, we report a new class of antimalarial protein …