The prepulse inhibition (PPI) of the acoustic startle reflex (ASR), as an index of sensorimotor
gating, is one of the most extensively used paradigms in the field of neuropsychiatric …

The origin of adult behavior and the possible pathogenesis of psychiatric disorders remain
elusive, but extensive research indicates that interaction of genes and environment play a …

Behavioral and brain development is influenced by both maternal and non-maternal aspects
of the postnatal environment and the precise nature of their interaction is the topic of an …

Environmental distresses occurring during the sensitive periods of early life may exacerbate
the vulnerability to develop physical and mental diseases in old age. Studies have shown …

Many neurodevelopmental disorders, including autism spectrum disorder (ASD), are
associated with changes in sensory processing and sensorimotor gating. The acoustic …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that results in
cognitive decline and a number of other neuropsychiatric symptoms. One area that is often …

Measuring animal behavior in the context of experimental manipulation is critical for
modeling, and understanding neuropsychiatric disease. Prepulse inhibition of the acoustic …

Inhibition plays a crucial role in many functional domains, such as cognition, emotion, and
actions. Studies on cognitive aging demonstrate changes in inhibitory mechanisms are age …

Sensory-motor gating, the process of filtering sensory stimuli to modulate motor responses,
is impaired in many psychiatric diseases but especially schizophrenia. Sensory-motor gating …

Acoustic startle response and its plasticity, eg, habituation and prepulse inhibition (PPI),
have been extensively investigated, being altered in several neuropsychiatric disorders. Yet …